1. Case-Control Study of Breast Cancer in India: Role of PERIOD3 Clock Gene Length Polymorphism and Chronotype.
- Author
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Wirth, Michael D., Burch, James B., Hébert, James R., Kowtal, Pradnya, Mehrotra-Kapoor, Aparna, Steck, Susan E., Hurley, Thomas G., Gupta, Prakash C., Pednekar, Mangesh S., Youngstedt, Shawn D., Hongmei Zhang, and Sarin, Rajiv
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BREAST cancer , *CASE-control method , *GENETIC polymorphisms , *TANDEM repeats , *NATIVE American women , *GENETIC mutation , *DISEASES - Abstract
Background: This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. Methods: This case-control study included sporadic, histologically confirmed BrCA cases ( n = 255) and controls ( n = 249) from India with data collection from 2010-2012. Results: Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23-4.81) or evening (OR = 2.55, 95% CI = 1.19-5.47) chronotype. Conclusions: Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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