1. Differential Expression of miR-125a-5p and let-7e Predicts the Progression and Prognosis of Non-Small Cell Lung Cancer
- Author
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Bin Luo, Jian Ying He, Li Yun Xu, Jiyuan An, Yan Yan Huang, Dong Dong Chen, Wang Yu Zhu, Yong Kui Zhang, Xiao Guang Liu, and Han Bo Le
- Subjects
Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Prognostic factor ,Lung Neoplasms ,Early detection ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,microRNA ,Biomarkers, Tumor ,Humans ,Medicine ,Differential expression ,Lung cancer ,Early Detection of Cancer ,business.industry ,General Medicine ,Cell Dedifferentiation ,Prognosis ,Serum samples ,medicine.disease ,respiratory tract diseases ,Survival Rate ,MicroRNAs ,Lymphatic Metastasis ,Disease Progression ,Female ,Non small cell ,business ,Mir 125a - Abstract
Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e and miR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly associated with NSCLC dedifferentiation. The lost expression of miR-125a-5p and let-7e was associated with shorter overall survival and let-7e was an independent prognostic factor for NSCLC patients. These five miRNA expressions should be further evaluated as biomarkers for the early detection and prognosis of NSCLC patients.
- Published
- 2014