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Start Over Author "Wilkinson, Jane" Journal cancer investigation
2 results on '"Wilkinson, Jane"'

2. Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance.

Author

Clark-Corrigall, John, Myssina, Svetlana, Michaelis, Martin, Cinatl Jr., Jindrich, Ahmed, Shafiq, and Carr-Wilkinson, Jane

Subjects
NEUROBLASTOMA, DOXORUBICIN, DRUG resistance, WNT proteins, CELLULAR signal transduction, GENE expression, RESEARCH funding, CELL lines, VINCRISTINE
Abstract

Neuroblastoma (NB) is a pediatric solid cancer with high fatality, relapses, and acquired resistance to chemotherapy, that requires new therapeutic approaches to improve survival. LGR5 is a receptor that potentiates WNT/signaling pathway and has been reported to promote development and survival in several adult cancers. In this study we investigated LGR5 expression in a panel of NB cell lines with acquired resistance to vincristine or doxorubicin. We show LGR5-LRP6 cooperation with enhanced expression in drug resistant NB cell lines compared to parental cells, suggesting a role for LGR5 in the emergence of drug resistance, warranting further investigation [ABSTRACT FROM AUTHOR]

Published
2023
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