1. Kindlin-2 promotes genome instability in breast cancer cells
- Author
-
Zhao, Ting, Guan, Lizhao, Yu, Yu, Pei, Xuelian, Zhan, Jun, Han, Ling, Tang, Yan, Li, Feng, Fang, Weigang, and Zhang, Hongquan
- Subjects
- *
BREAST cancer , *CANCER invasiveness , *APOPTOSIS , *CHROMOSOME abnormalities , *GENE expression , *COMPARATIVE genomic hybridization , *FOCAL adhesions - Abstract
Abstract: Kindlin-2, as a focal adhesion protein, has been found to regulate tumor progression. However, the mechanism underlying Kindlin-2 regulation of tumor progression is largely unknown. Here, we report that Kindlin-2 regulates breast cancer cell proliferation, apoptosis and chromosomal abnormalities in both gain and loss of function assays. Functionally, overexpression of Kindlin-2 promotes tumor formation in implanted xenograft while knockdown of Kindlin-2 inhibits tumor growth in mice. Mechanistically, an array-based comparative genomic hybridization and karyotype analyses indicate that ectopic expression of Kindlin-2 leads to genome instability in breast cancer cells. Our data suggest a novel mechanism that Kindlin-2 regulates breast cancer progression by inducing genome instability. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF