1. Strategies in functional proteomics: Unveiling the pathways to precision oncology.
- Author
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Favicchio, Rosy, Thepaut, Chloe, Zhang, Hua, Arends, Richard, Stebbing, Justin, and Giamas, Georgios
- Subjects
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ONCOLOGY research , *DRUG development , *PROTEOMICS , *HEALTH outcome assessment , *BIOMARKERS , *ANTINEOPLASTIC agents , *PROTEIN metabolism , *ANIMAL experimentation , *CELLULAR signal transduction , *DRUG therapy , *DATABASES , *DRUG design , *METABOLISM , *MOLECULAR diagnosis , *PROTEINS , *RESEARCH funding , *TUMORS , *BIOINFORMATICS , *PREDICTIVE tests , *PATIENT selection - Abstract
Personalised strategies in cancer care are required to overcome the therapeutic challenges posed by variability between patients and disease subsets. To this end, enhanced precision tools must be developed to describe the molecular drivers of malignant proliferation. Such tools must also identify druggable targets and biomarkers in order to provide essential information regarding drug development and therapeutic outcome. Here we discuss how proteomics-based approaches provide a set of viable methodologies capable of delivering quantitative information throughout the main stages of personalised oncology and a ratiometric platform that delivers systems-wide methods for drug evaluation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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