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1. miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells.

Author

Vicinus B, Rubie C, Faust SK, Frick VO, Ghadjar P, Wagner M, Graeber S, and Schilling MK

Subjects
Caco-2 Cells, Cell Line, Tumor, Chemokine CCL20 genetics, Chemokine CCL20 metabolism, Colorectal Neoplasms metabolism, Down-Regulation, Humans, Mutagenesis, Site-Directed methods, RNA, Messenger genetics, Transfection methods, 3' Untranslated Regions, Chemokine CCL20 biosynthesis, Colorectal Neoplasms genetics, MicroRNAs genetics, MicroRNAs metabolism
Abstract

As deregulation of miRNAs and chemokine CCL20 was shown to play a role in colorectal cancer (CRC) pathogenesis, we analyzed the functional interactions of candidate miRNAs with CCL20 mRNA. After target prediction software programs indicated a role for miR-21 in CCL20 regulation, we applied the luciferase reporter assay system to demonstrate that miR-21 functionally interacts with the 3'UTR of CCL20 mRNA and down-regulates CCL20 in miR-21 mimic transfected CRC cell lines (Caco-2, SW480 and SW620). Thus, regulation of CCL20 expression by miR-21 might be a regulatory mechanism involved in progression of CRC., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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