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Start Over Author "Jeon, Won Kyung" Journal cancer letters
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3. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells

Author

Kwon, Ho-Keun, Jeon, Won Kyung, Hwang, Ji-Sun, Lee, Choong-Gu, So, Jae-Seon, Park, Jin-A, Ko, Byoung Seob, and Im, Sin-Hyeog

Subjects
*CANCER invasiveness, *NEOVASCULARIZATION, *T cells, *HERBAL medicine, *ANTINEOPLASTIC agents, *GENE expression, *CELL-mediated cytotoxicity, *CINNAMON
Abstract

Abstract: Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8+ T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment. [Copyright &y& Elsevier]

Published
2009
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