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Start Over Author "Kun-Ming Wen" Journal cancer letters
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1. Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: effects associated with STAT3/Survivin

Author

Xingye Wu, Kun-ming Wen, Jiang Qian, Wangsheng Chen, Zhongxue Fu, and Jihong Feng

Subjects
STAT3 Transcription Factor, Cancer Research, Organoplatinum Compounds, Colorectal cancer, Survivin, Apoptosis, Mice, SCID, Biology, Oct-4, Inhibitor of Apoptosis Proteins, Small hairpin RNA, Mice, Cancer stem cell, Antigens, CD, Cell Line, Tumor, medicine, Animals, Humans, AC133 Antigen, STAT3, Glycoproteins, Gene knockdown, medicine.disease, Oxaliplatin, Hyaluronan Receptors, Oncology, Drug Resistance, Neoplasm, biology.protein, Cancer research, Neoplastic Stem Cells, Colorectal Neoplasms, Peptides, Octamer Transcription Factor-3
Abstract

Cancer stem cells (CSCs) have been implicated in multidrug resistance, a phenomenon responsible for the failure of cancer chemotherapy. However, the underlying mechanisms are still unclear. In our study, we established two oxaliplatin-resistant colorectal cancer cell lines displaying some CSCs characteristics. Oct4 overexpression was observed in these two lines. We performed Oct4 knock down by lentiviral vector-mediated specific shRNA. Knockdown increased apoptosis, decreased CSCs marker expression and weakened tumorigenicity in drug-resistant cell lines. In conclusion, we show that these events can be at least in part attributed to the STAT3/Survivin pathway.

Published
2012

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