1. Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer
- Author
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Pasquale Saponaro, Arcangelo Pagliarulo, Roberto Perrone, Nicola Antonio Colabufo, Mauro Niso, Francesco Berardi, Vincenzo Pagliarulo, Savina Ferorelli, and Marialessandra Contino
- Subjects
Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Radioligand Assay ,medicine ,Radioligand ,Humans ,Receptors, sigma ,Neoplasm Invasiveness ,Urothelium ,Receptor ,Aged ,Neoplasm Staging ,Carcinoma, Transitional Cell ,Chemistry ,Cancer ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Ki-67 Antigen ,Oncology ,Urinary Bladder Neoplasms ,Cell culture ,Cancer research ,Carcinoma, Squamous Cell ,Plasmacytoma ,Female - Abstract
Sigma 2 (σ 2 ) receptor proteins are overexpressed in several tissues and tumour cell lines. Although the biomolecular mechanism of this overexpression must be elucidated, σ 2 receptor was considered a potential biomarker for monitoring solid tumour proliferation. In this study, we verified first σ 2 receptor overexpression by saturation analysis with radioligand in six human bladder cancer specimens, then if a possible correlation could be established between σ 2 overexpression and tumour tissue stage and grade. The results displayed that σ 2 receptor protein was normally expressed in human bladder and overexpressed in the case of high-grade transitional cell carcinomas. Moreover, these receptors were undetected in a low-grade squamous cell carcinoma and in a very rare form of anaplastic, large cells plasmacytoid cancer.
- Published
- 2005