1. Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma
- Author
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Kuniaki Arai, Eishiro Mizukoshi, Yoshio Sakai, Masaaki Kitahara, Yoshiko Takata, Akiko Nakada, Taro Yamashita, Shuichi Kaneko, Takeshi Terashima, Tatsuya Yamashita, Yasunari Nakamoto, Kaheita Kakinoki, and Fumitaka Arihara more...
- Subjects
Male ,Cancer Research ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,Regulatory T cell ,T cell ,chemical and pharmacologic phenomena ,Biology ,T-Lymphocytes, Regulatory ,medicine ,Humans ,In patient ,IL-2 receptor ,Aged ,Liver Neoplasms ,hemic and immune systems ,CD45RO ,Dendritic cell ,Middle Aged ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,Oncology ,Case-Control Studies ,Immunology ,T cell subset ,Intracellular cytokine ,Cancer research ,Disease Progression ,Leukocyte Common Antigens ,Female ,Liver cancer - Abstract
金沢大学先進予防医学研究センター / 金沢大学医薬保健研究域医学系, The purpose of this study was to assess the properties of CD4+CD25high/low/negative T cell subsets and analyze their relation with dendritic cells (DCs) in patients with hepatocellular carcinoma (HCC). In HCC patients, the prevalence of CD45RO+ cells in CD4+CD25high T cells was increased and associated with higher frequencies of plasmacytoid DCs. Larger proportions of this T cell subset were detected in the patients with larger tumor burdens. These results suggest that increased frequencies of the CD45RO+ subset in CD4+CD25high Tregs in HCC patients may establish the immunosuppressive environment cooperatively with tolerogenic plasmacytoid DCs to promote disease progression of liver cancer. © 2011. more...
- Published
- 2010