1. Dysregulation of ncRNAs located at the DLK1‑DIO3 imprinted domain: involvement in urological cancers
- Author
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Xiao Wang, Huaqing Yan, Xin Xu, Liping Xie, Haixiang Shen, Song Wang, Jiangfeng Li, Mingjie Xu, Ke Jin, Yufan Ying, and Haiyun Xie
- Subjects
0301 basic medicine ,MEG3 ,DMRs ,epigenetics ,ncRNAs ,Computational biology ,Review ,Biology ,Non-coding RNA ,regulatory network ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Differentially methylated regions ,Oncology ,030220 oncology & carcinogenesis ,microRNA ,DLK1-DIO3 imprinted domain ,Epigenetics ,Small nucleolar RNA ,Genomic imprinting ,urological cancers ,Gene - Abstract
Genomic imprinting has been found to be involved in human physical development and several diseases. The DLK1-DIO3 imprinted domain is located on human chromosome 14 and contains paternally expressed protein-coding genes (DLK1, RTL1, DIO3) and numerous maternally expressed ncRNA genes (MEG3, MEG8, antisense RTL1, miRNAs, piRNAs, and snoRNAs). Emerging evidence has implicated that dysregulation of the DLK1-DIO3 imprinted domain especially the imprinted ncRNAs is critical for tumor progressions. Multiple miRNAs and lncRNAs have been investigated in urological cancers, of which several are transcribed from this domain. In this review, we present current data about the associated miRNAs, lncRNAs, and piRNAs and the regulation of differentially methylated regions methylation status in the progression of urological cancers and preliminarily propose certain concepts about the potential regulatory networks involved in DLK1-DIO3 imprinted domain.
- Published
- 2019