1. Post-treatment urinary sarcosine as a predictor of recurrent relapses in patients with prostate cancer
- Author
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Dalibor Pacík, Mariana Plevová, Natalia Cernei, Martina Raudenská, Zuzana Lackova, Ondrej Zitka, Zbynek Heger, Alena Sorokac-Kubolkova, Jaromír Gumulec, Vojtech Adam, and Vladislav Strmiska
- Subjects
Male ,0301 basic medicine ,Cancer Research ,Prostate biopsy ,medicine.medical_treatment ,Prostatic Hyperplasia ,Prostate cancer ,chemistry.chemical_compound ,0302 clinical medicine ,Recurrence ,Postoperative Period ,10. No inequality ,Original Research ,media_common ,Aged, 80 and over ,relapse ,medicine.diagnostic_test ,Prostatectomy ,prostate cancer ,3. Good health ,Treatment Outcome ,Oncology ,030220 oncology & carcinogenesis ,outcome ,Adenocarcinoma ,medicine.medical_specialty ,Sarcosine ,Urinary system ,media_common.quotation_subject ,Urology ,survival ,Urination ,03 medical and health sciences ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Retrospective Studies ,Transurethral resection of the prostate ,business.industry ,Prostatic Neoplasms ,Clinical Cancer Research ,medicine.disease ,030104 developmental biology ,chemistry ,Neoplasm Recurrence, Local ,business ,Biomarkers - Abstract
To date, there has been no evidence regarding the association between urinary sarcosine content and prostate cancer survival. Our main objective was to investigate whether levels of post‐treatment urinary sarcosine are associated with relapse. The inclusion criteria were (in accordance with EAU 2017) as follows: histopathologically verified adenocarcinoma in prostate biopsy cores or specimens from transurethral resection of the prostate (TURP) or prostatectomy for benign prostatic enlargement (BPE) with retained ability to urinate. The median follow‐up was 53 months. In the study, we retrospectively evaluated a cohort of 511 patients with prostate cancer with various risk factors and treatment strategies. Post‐treatment sarcosine levels were elevated in 266 (52%) patients and highly elevated (≥200 nmol/L) in 71 (13%) patients. Urinary sarcosine content was significantly associated with number of relapses that patients experienced, P = 0.002 for sarcosine ≥200 vs ≤30 nmol/L. Multivariate analysis revealed that sarcosine was an independent predictor of recurrent relapses (≥2 relapses with an intermediate period of remission), HR = 3.89 (95% CI 1.29‐11.7) for sarcosine >200 vs
- Published
- 2018
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