1. [Normal tissue tolerance to external beam radiation therapy: liver].
- Author
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De Bari B, Pointreau Y, Rio E, Mirabel X, and Mornex F
- Subjects
- Cholesterol metabolism, Glucose metabolism, Hepatic Veins anatomy & histology, Hepatic Veins radiation effects, Humans, Lipids physiology, Liver anatomy & histology, Liver physiology, Liver Neoplasms radiotherapy, Liver Neoplasms secondary, Neoplasm Metastasis radiotherapy, Portal Vein anatomy & histology, Portal Vein radiation effects, Proteins metabolism, Radiation Injuries diagnostic imaging, Radionuclide Imaging, Radiosurgery adverse effects, Radiotherapy methods, Radiotherapy Dosage, Radiotherapy, Conformal adverse effects, Radiotherapy, Conformal methods, Vena Cava, Inferior anatomy & histology, Vena Cava, Inferior radiation effects, Liver radiation effects, Radiation Injuries epidemiology, Radiation Tolerance, Radiotherapy adverse effects
- Abstract
The liver is a large abdominal organ in the right hypondrium. Because of its anatomical situation, it is near many abdominal PTVs as well as some lower thoracic PVTs. The liver could also be at the same time the target (for irradiation of liver metastases or primary liver tumours) and organ at risk (OAR). Radiation-induced liver disease (RILD) is radiobiologically the normal tissue complication probability (NTCP), i.e., the clinical event limiting the total dose that could be delivered. This review describes radiobiological criteria justifying the NTCP data, and recommendations for conformal 3D radiotherapy and stereotactic liver irradiation., (Copyright (c) 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.)
- Published
- 2010
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