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Your search keyword '"D'Angelo, Fulvio"' showing total 6 results
Start Over Author "D'Angelo, Fulvio" Journal cancer research
6 results on '"D'Angelo, Fulvio"'

1. The epigenetic evolution of glioma is determined by the IDH1 mutation status and treatment regimen

Author

Malta, Tathiane M., primary, Sabedot, Thais S., additional, Morosini, Natalia S., additional, Datta, Indrani, additional, Garofano, Luciano, additional, Vallentgoed, Wies R., additional, Varn, Frederick S., additional, Aldape, Kenneth, additional, D'Angelo, Fulvio, additional, Bakas, Spyridon, additional, Barnholtz-Sloan, Jill S., additional, Gan, Hui K., additional, Hasanain, Mohammad, additional, Hau, Ann-Christin, additional, Johnson, Kevin C., additional, Cazacu, Simona, additional, deCarvalho, Ana C., additional, Khasraw, Mustafa, additional, Kocakavuk, Emre, additional, Kouwenhoven, Mathilde C.M., additional, Migliozzi, Simona, additional, Niclou, Simone P., additional, Niers, Johanna M., additional, Ormond, D. Ryan., additional, Paek, Sun Ha, additional, Reifenberger, Guido, additional, Sillevis Smitt, Peter A., additional, Smits, Marion, additional, Stead, Lucy F., additional, van den Bent, Martin J., additional, Van Meir, Erwin G., additional, Walenkamp, Annemiek, additional, Weiss, Tobias, additional, Weller, Michael, additional, Westerman, Bart A., additional, Ylstra, Bauke, additional, Wesseling, Pieter, additional, Lasorella, Anna, additional, French, Pim J., additional, Poisson, Laila M., additional, Consortium, The GLASS, additional, Verhaak, Roel G.W., additional, Iavarone, Antonio, additional, and Noushmehr, Houtan, additional

Published
2023
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2. Abstract 5621: Multi-parametric MRI maps regional heterogeneity of high grade glioma phenotypes

Author

Flick, Matthew, primary, Weiskittel, Taylor, additional, Meng-Lin, Kevin, additional, D'Angelo, Fulvio, additional, Caruso, Francesca, additional, Ensign, Shannon, additional, Blomquist, Mylan, additional, Wang, Luija, additional, Sereduk, Christopher, additional, De Leon, Gustavo, additional, Nespodzany, Ashley, additional, Urcuyo, Javier, additional, Gonzalez, Ashlynn, additional, Curtin, Lee, additional, Singleton, Kyle, additional, Anil, Aliya, additional, Simmineh, Natenael, additional, Lewis, Erika, additional, Noviello, Teresa, additional, Patel, Reyna, additional, Wang, Panwen, additional, Wang, Junwen, additional, Eschbacher, Jennifer, additional, Hawkins-Daarud, Andrea, additional, Jackson, Pamela, additional, Smith, Kris, additional, Nakaji, Peter, additional, Bendok, Bernard, additional, Zimmerman, Richard, additional, Krishna, Chandan, additional, Patra, Devi, additional, Patel, Naresh, additional, Lyons, Mark, additional, Neal, Matthew, additional, Donev, Kliment, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Beeman, Scott, additional, Zhou, Yuxiang, additional, Baxter, Leslie, additional, Plaisier, Christopher, additional, Li, Jing, additional, Li, Hu, additional, Lasorella, Anna, additional, Quarles, Chad, additional, Swanson, Kristin, additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Tran, Nhan, additional, and Hu, Leland, additional

Published
2023
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3. Abstract 1507: Multiregional sampling of high grade glioma identifies regional biologic signatures

Author

Blomquist, Mylan R., primary, Hu, Leland S., additional, D'Angelo, Fulvio, additional, Weiskittel, Taylor M., additional, Caruso, Francesca P., additional, Ensign, Shannon P. Fortin, additional, Sereduk, Christopher, additional, De Leon, Gustavo, additional, Curtin, Lee, additional, Urcuyo, Javier, additional, Gonzalez, Ashlynn, additional, Nespodzany, Ashley, additional, Noviello, Teresa, additional, Eschbacher, Jennifer M., additional, Smith, Kris A., additional, Nakaji, Peter, additional, Bendok, Bernard R., additional, Zimmerman, Richard S., additional, Krishna, Chandan, additional, Patra, Devi, additional, Patel, Naresh, additional, Lyons, Mark, additional, Donev, Kliment, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Lasorella, Anna, additional, Swanson, Kristin R., additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, and Tran, Nhan L., additional

Published
2023
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4. Abstract 4014: Pathway based analysis of glioblastoma by multi-omics with applications in targeted therapy, prognosis and probabilistic classification

Author

Migliozzi, Simona, primary, Oh, Young Taek, additional, Garofano, Luciano, additional, Mohammad, Hasanain, additional, D'Angelo, Fulvio, additional, Najac, Ryan D., additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Sarkaria, Jann N., additional, Ceccarelli, Michele, additional, Sanson, Marc, additional, Lasorella, Anna, additional, and Iavarone, Antonio, additional

Published
2022
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5. Abstract 770: Multiregional imaging and genomic analysis in high-grade IDH-mutant astrocytoma identifies intratumor subclones with aggressive features

Author

Ensign, Shannon P. Fortin, primary, D'Angelo, Fulvio, additional, Caruso, Francesca P., additional, Sereduk, Christopher, additional, Singleton, Kyle, additional, Eschbacher, Jennifer, additional, Mazza, Gina, additional, Mrugala, Maciej, additional, Porter, Alyx, additional, Bendok, Bernard, additional, Zimmerman, Richard, additional, Smith, Kris, additional, Nakaji, Peter, additional, Swanson, Kamala, additional, Wang, Junwen, additional, Semmineh, Nathenael, additional, Quarles, Christopher, additional, Lasorella, Anna, additional, Swanson, Kristin, additional, Ceccarelli, Michele, additional, Iavarone, Antonio, additional, Hu, Leland, additional, and Tran, Nhan L., additional

Published
2022
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6. The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.

Author

Malta TM, Sabedot TS, Morosini NS, Datta I, Garofano L, Vallentgoed W, Varn FS, Aldape K, D'Angelo F, Bakas S, Barnholtz-Sloan JS, Gan HK, Hasanain M, Hau AC, Johnson KC, Cazacu S, deCarvalho AC, Khasraw M, Kocakavuk E, Kouwenhoven MCM, Migliozzi S, Niclou SP, Niers JM, Ormond DR, Paek SH, Reifenberger G, Sillevis Smitt PA, Smits M, Stead LF, van den Bent MJ, Van Meir EG, Walenkamp A, Weiss T, Weller M, Westerman BA, Ylstra B, Wesseling P, Lasorella A, French PJ, Poisson LM, Verhaak RGW, Iavarone A, and Noushmehr H

Subjects
Humans, Epigenesis, Genetic, Epigenomics, Mutation, Neoplasm Recurrence, Local genetics, Tumor Microenvironment, Brain Neoplasms pathology, Glioma pathology, Isocitrate Dehydrogenase genetics, Isocitrate Dehydrogenase metabolism
Abstract

Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of global methylation. The epigenome of IDHmut gliomas showed initial high levels of genome-wide DNA methylation that was progressively reduced to levels similar to those of IDHwt tumors. Integration of epigenomics, gene expression, and functional genomics identified HOXD13 as a master regulator of IDHmut astrocytoma evolution. Furthermore, relapse of IDHmut tumors was accompanied by histologic progression that was associated with survival, as validated in an independent cohort. Finally, the initial cell composition of the tumor microenvironment varied between IDHwt and IDHmut tumors and changed differentially following treatment, suggesting increased neoangiogenesis and T-cell infiltration upon treatment of IDHmut gliomas. This study provides one of the largest cohorts of paired longitudinal glioma samples with epigenomic, transcriptomic, and genomic profiling and suggests that treatment of IDHmut glioma is associated with epigenomic evolution toward an IDHwt-like phenotype., Significance: Standard treatments are related to loss of DNA methylation in IDHmut glioma, resulting in epigenetic activation of genes associated with tumor progression and alterations in the microenvironment that resemble treatment-naïve IDHwt glioma., (©2023 The Authors; Published by the American Association for Cancer Research.)

Published
2024
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