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16 results on '"Dirks, Peter"'

2. Abstract 5724: Revelation of shared transcriptional gradients in glioblastoma tumors and cultured glioma stem cells

Author

Whitley, Owen K., primary, Richards, Laura M., additional, Cavalli, Florence, additional, Guilhamon, Paul, additional, Coutinho, Fiona, additional, Kushida, Michelle, additional, Luchman, H. Artee, additional, Weiss, Samuel, additional, Lupien, Mathieu, additional, Dirks, Peter, additional, Pugh, Trevor, additional, and Bader, Gary, additional

Published
2020
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3. Abstract 3438: Hypoxia inhibits BMP4-induced astrocytic differentiation in glioma stem cells

Author

Wu, Ronald S., primary, Liedtke, Elisabeth, additional, Mansouri, Sheila, additional, Brazier, Samantha, additional, Guilhamon, Paul, additional, Park, Nicole I., additional, Chen, Eric, additional, Lupien, Mathieu, additional, De Carvalho, Daniel D., additional, Dirks, Peter G., additional, Zadeh, Gelareh, additional, and Wouters, Bradley G., additional

Published
2020
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4. ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma

Author

Sachdeva, Rohit, primary, Wu, Megan, additional, Smiljanic, Sandra, additional, Kaskun, Oleksandra, additional, Ghannad-Zadeh, Kimia, additional, Celebre, Angela, additional, Isaev, Keren, additional, Morrissy, A. Sorana, additional, Guan, Jennifer, additional, Tong, Jiefei, additional, Chan, Jeffrey, additional, Wilson, Taylor M., additional, Al-Omaishi, Sayf, additional, Munoz, David G., additional, Dirks, Peter B., additional, Moran, Michael F., additional, Taylor, Michael D., additional, Reimand, Jüri, additional, and Das, Sunit, additional

Published
2019
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5. Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

Author

Hoffman, Mary, primary, Gillmor, Aaron H., additional, Kunz, Daniel J., additional, Johnston, Michael J., additional, Nikolic, Ana, additional, Narta, Kiran, additional, Zarrei, Mehdi, additional, King, Jennifer, additional, Ellestad, Katrina, additional, Dang, Ngoc Ha, additional, Cavalli, Florence M.G., additional, Kushida, Michelle M., additional, Coutinho, Fiona J., additional, Zhu, Yuankun, additional, Luu, Betty, additional, Ma, Yussanne, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Marra, Marco A., additional, Taylor, Michael D., additional, Pugh, Trevor J., additional, Dirks, Peter B., additional, Strother, Douglas, additional, Lafay-Cousin, Lucie, additional, Resnick, Adam C., additional, Scherer, Stephen, additional, Senger, Donna L., additional, Simons, Benjamin D., additional, Chan, Jennifer A., additional, Morrissy, A. Sorana, additional, and Gallo, Marco, additional

Published
2019
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6. Abstract B09: DNA polymerase mutations trigger rapid onset of ultra-hypermutant malignant brain tumors in children with biallelic mismatch repair deficiency

Author

Shlien, Adam, primary, Campbell, Brittany B., additional, Borja, Richard de, additional, Alexandrov, Ludmil B., additional, Merico, Daniele, additional, Wedge, David, additional, Loo, Peter Van, additional, Tarpey, Patrick S., additional, Coupland, Paul, additional, Pollett, Aaron, additional, Lipman, Tatiana, additional, Heidari, Abolfazl, additional, Deshmukh, Shriya, additional, Gerstung, Moritz, additional, Merino, Diana, additional, Ramakrishna, Manasa, additional, Remke, Marc, additional, Arnold, Roland, additional, Panigrahi, Gagan B., additional, Afzal, Samina, additional, Larouche, Valerie, additional, Druker, Harriet, additional, Lerner-Ellis, Jordan, additional, Mistry, Matthew, additional, Dvir, Rina, additional, Grant, Ronald, additional, Elhasid, Ronit, additional, Farah, Roula, additional, Taylor, Glenn P., additional, Nathan, Paul C., additional, Alexander, Sarah, additional, Ben-Shachar, Shay, additional, Jabado, Nada, additional, Gallinger, Steven, additional, Constantini, Shlohmi, additional, Dirks, Peter, additional, Huang, Annie, additional, Scherer, Steven W., additional, Grundy, Richard G., additional, Durno, Carol, additional, Aronson, Melyssa, additional, Meyn, M Stephen, additional, Taylor, Michael D., additional, Pursell, Zachary F., additional, Pearson, Christopher E., additional, Malkin, David, additional, Futreal, P Andrew, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, Campbell, Peter J., additional, and Tabori, Uri, additional

Published
2015
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7. Abstract A20: hTERT promoter hypermethylation is a cancer signature which predicts survival and response to targeted therapy in pediatric nervous system tumors

Author

castelo-branco, Pedro, primary, Choufani, Sanaa, additional, Mack, Stephen, additional, Gallagher, Denis, additional, Zhang, Cindy, additional, Lipman, Tatiana, additional, Zhukova, Nataliya, additional, Walker, Erin J., additional, Merino, Diana, additional, Jonathan, Jonathan D., additional, Elizabeth, Cynthia, additional, Alon, Noa, additional, Zhang, Libo, additional, Hovestadt, Volker, additional, Kool, Marcel, additional, Jones, David TW, additional, Croul, Sidney, additional, Hawkins, Cynthia, additional, Hitzler, Johann, additional, Wang, Jean C.Y., additional, Malkin, David, additional, Baruchel, Sylvain, additional, Dirks, Peter B., additional, Pfister, Stefan, additional, Taylor, Michael, additional, Weksberg, Rosanna, additional, and Tabori, Uri, additional

Published
2014
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11. Monoallelic Expression Determines Oncogenic Progression and Outcome in Benign and Malignant Brain Tumors

Author

Walker, Erin J., primary, Zhang, Cindy, additional, Castelo-Branco, Pedro, additional, Hawkins, Cynthia, additional, Wilson, Wes, additional, Zhukova, Nataliya, additional, Alon, Noa, additional, Novokmet, Ana, additional, Baskin, Berivan, additional, Ray, Peter, additional, Knobbe, Christiane, additional, Dirks, Peter, additional, Taylor, Michael D., additional, Croul, Sidney, additional, Malkin, David, additional, and Tabori, Uri, additional

Published
2012
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16. Identification of a cancer stem cell in human brain tumors.

Author

Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, and Dirks PB

Subjects
AC133 Antigen, Adolescent, Antigens, CD, Astrocytoma genetics, Astrocytoma metabolism, Astrocytoma pathology, Brain Neoplasms genetics, Brain Neoplasms metabolism, Cell Differentiation physiology, Cell Division physiology, Cell Movement physiology, Child, Child, Preschool, Female, Glioblastoma genetics, Glioblastoma metabolism, Glioblastoma pathology, Glycoproteins biosynthesis, Humans, Immunohistochemistry, Infratentorial Neoplasms genetics, Infratentorial Neoplasms metabolism, Infratentorial Neoplasms pathology, Karyotyping, Male, Medulloblastoma genetics, Medulloblastoma metabolism, Medulloblastoma pathology, Neoplastic Stem Cells metabolism, Neurons cytology, Peptides, Phenotype, Brain Neoplasms pathology, Neoplastic Stem Cells pathology
Abstract

Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some malignancies that the tumor clone is heterogeneous with respect to proliferation and differentiation. In human leukemia, the tumor clone is organized as a hierarchy that originates from rare leukemic stem cells that possess extensive proliferative and self-renewal potential, and are responsible for maintaining the tumor clone. We report here the identification and purification of a cancer stem cell from human brain tumors of different phenotypes that possesses a marked capacity for proliferation, self-renewal, and differentiation. The increased self-renewal capacity of the brain tumor stem cell (BTSC) was highest from the most aggressive clinical samples of medulloblastoma compared with low-grade gliomas. The BTSC was exclusively isolated with the cell fraction expressing the neural stem cell surface marker CD133. These CD133+ cells could differentiate in culture into tumor cells that phenotypically resembled the tumor from the patient. The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC.

Published
2003

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