Search

Your search keyword '"Gu, Jian"' showing total 61 results
Start Over Author "Gu, Jian" Journal cancer research
61 results on '"Gu, Jian"'

1. Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer

Author

Sun, Xiaohui, primary, Verma, Shiv Prakash, additional, Jia, Guochong, additional, Wang, Xinjun, additional, Ping, Jie, additional, Guo, Xingyi, additional, Shu, Xiao-Ou, additional, Chen, Jianhong, additional, Derkach, Andriy, additional, Cai, Qiuyin, additional, Liang, Xiaolin, additional, Long, Jirong, additional, Offit, Kenneth, additional, Oh, Jung Hun, additional, Reiner, Anne S., additional, Watt, Gordon P., additional, Woods, Meghan, additional, Yang, Yaohua, additional, Ambrosone, Christine B., additional, Ambs, Stefan, additional, Chen, Yu, additional, Concannon, Patrick, additional, Garcia-Closas, Montserrat, additional, Gu, Jian, additional, Haiman, Christopher A., additional, Hu, Jennifer J., additional, Huo, Dezheng, additional, John, Esther M., additional, Knight, Julia A., additional, Li, Christopher I., additional, Lynch, Charles F., additional, Mellemkjaer, Lene, additional, Nathanson, Katherine L., additional, Nemesure, Barbara, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Pal, Tuya, additional, Palmer, Julie R., additional, Press, Michael F., additional, Sanderson, Maureen, additional, Sandler, Dale P., additional, Troester, Melissa A., additional, Zheng, Wei, additional, Bernstein, Jonine L., additional, Buas, Matthew F., additional, and Shu, Xiang, additional

Published
2024
Full Text
View/download PDF

2. Pathway-based serum microRNA profiling and survival in patients with advanced stage non-small cell lung cancer.

Author

Wang, Yan, Gu, Jian, Roth, Jack, Hildebrandt, Michelle, Ye, Yuanqing, Minna, John, Wu, Xifeng, and Lippman, Scott

Subjects
Biomarkers, Tumor, Carcinoma, Non-Small-Cell Lung, Female, Gene Expression Profiling, Humans, Kaplan-Meier Estimate, Lung Neoplasms, Male, MicroRNAs, Middle Aged, Neoplasm Staging, Oligonucleotide Array Sequence Analysis, Proportional Hazards Models
Abstract

This study was designed to identify TGF-β signaling pathway-related serum microRNAs (miRNA) as predictors of survival in advanced non-small cell lung cancer (NSCLC). Serum samples from 391 patients with advanced NSCLC were collected before treatment. Global miRNA microarray expression profiling based on sera from four patients with good survival (>24 months) and four patients with poor survival (

Published
2013

3. Abstract 5601: Oncomine™ dx express CE-IVD liquid biopsy assay for non-small cell lung cancer: Performance review and analytical validation

Author

Siepert, Nicholas, primary, Schageman, Jeoffrey, additional, Gu, Jian, additional, Jayaweera, Thilanka, additional, Jasti, Madhu, additional, He, Luming, additional, Wunch, Stephen, additional, Ostrowska, Emilia, additional, Delacour, Tasha, additional, Hassell, Diarra, additional, Bowden, Thomas, additional, Garcia, Daniela, additional, Tong, Stephanie, additional, Raut, Swasti, additional, Ezzedine, Nader, additional, Martinez, Elliott, additional, and Bramlett, Kelli, additional

Published
2023
Full Text
View/download PDF

4. Abstract 2939: Automation meets reliability: Use of Oncomine࣪precision assay on the Genexus࣪system for accurate identification of cancer biomarkers in FFPE and liquid biopsy samples

Author

Jayaweera, Thilanka, primary, Siepert, Nicholas, additional, Hradecky, Brian, additional, Ostrowska, Emilia, additional, Casuga, Iris, additional, Lea, kristy, additional, Kshatriya, Priyanka, additional, Gu, Jian, additional, Schageman, Jeff, additional, Cao, Ru, additional, Cheng, Angie, additional, and Bramlett, Kelli, additional

Published
2022
Full Text
View/download PDF

8. Abstract 3118: Next generation sequencing assay for detection of gene fusions and exon deletion events in tissue and liquid biopsy samples at very low frequency

Author

Gottimukkala, Rajesh K., primary, Hyland, Fiona C., additional, Marcovitz, Amir, additional, Schageman, Jeoffrey, additional, Bagai, Varun, additional, Cao, Ru, additional, Williams, Paul D., additional, Myrand, Scott P., additional, Gu, Jian, additional, Sadis, Seth, additional, and Bramlett, Kelli S., additional

Published
2020
Full Text
View/download PDF

22. An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin

Author

Garner, Andrew P., primary, Bialucha, Carl U., additional, Sprague, Elizabeth R., additional, Garrett, Joan T., additional, Sheng, Qing, additional, Li, Sharon, additional, Sineshchekova, Olga, additional, Saxena, Parmita, additional, Sutton, Cammie R., additional, Chen, Dongshu, additional, Chen, Yan, additional, Wang, Huiqin, additional, Liang, Jinsheng, additional, Das, Rita, additional, Mosher, Rebecca, additional, Gu, Jian, additional, Huang, Alan, additional, Haubst, Nicole, additional, Zehetmeier, Carolin, additional, Haberl, Manuela, additional, Elis, Winfried, additional, Kunz, Christian, additional, Heidt, Analeah B., additional, Herlihy, Kara, additional, Murtie, Joshua, additional, Schuller, Alwin, additional, Arteaga, Carlos L., additional, Sellers, William R., additional, and Ettenberg, Seth A., additional

Published
2013
Full Text
View/download PDF

24. Abstract LB-27: Metabolomic profiling identifies bilirubin as a novel serum marker for lung cancer.

Author

Zhang, Fanmao, primary, Wen, Chi Pang, additional, Liang, Dong, additional, Skinner, Heath, additional, Gu, Jian, additional, Chow, Wong-Ho, additional, Ye, Yuanqing, additional, Hildebrandt, Michelle A.T., additional, Pu, Xia, additional, Huang, Maosheng, additional, Tsai, Min Kuang, additional, Tsao, Chwen Keng, additional, and Wu, Xifeng, additional

Published
2013
Full Text
View/download PDF

29. Abstract 2929: Predictors of survival in never-smokers with non-small cell lung cancer: A large-scale, two-phase genetic study

Author

Pu, Xia, primary, Ye, Yuanqing, additional, Spitz, Margaret R., additional, Wang, Liang, additional, Gu, Jian, additional, Lippman, Scott M., additional, Hildebrandt, Michelle AT, additional, Hong, Waun K., additional, Minna, John D., additional, Roth, Jack A., additional, Yang, Ping, additional, and Wu, Xifeng, additional

Published
2012
Full Text
View/download PDF

50. Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol.

Author

Wu S, Zhu H, Gu J, Zhang L, Teraishi F, Davis JJ, Jacob DA, and Fang B

Subjects
Cell Division drug effects, Cell Line, Tumor, Down-Regulation drug effects, Drug Screening Assays, Antitumor, Fibroblasts drug effects, Humans, Proto-Oncogene Proteins c-bcl-2 genetics, Transfection, bcl-X Protein, Antineoplastic Agents pharmacology, Apoptosis drug effects, Chlorobenzenes pharmacology, Ethanolamines pharmacology, Proto-Oncogene Proteins c-bcl-2 biosynthesis
Abstract

In a search for new anticancer agents, we identified that 2[[3-(2,3-dichlorophenoxy) propyl]amino]ethanol (2,3-DCPE) induced apoptosis more effectively in various cancer cells than in normal human fibroblasts. We further evaluated the cell-killing effects of this compound in vitro in several human cancer cell lines and normal human fibroblasts. A cell viability assay showed that IC(50)s for human colon cancer cell lines LoVo and DLD-1, for human lung cancer cell lines H1299 and A549, and for normal human fibroblasts were 0.89, 1.95, 2.24, 2.69, and 12.6 micro M, respectively. Subsequent studies revealed that 2,3-DCPE could cause cleavage of caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase and release of cytochrome c in cancer cells but not in normal human fibroblasts. Our data also showed that 2,3-DCPE attenuated the protein level of Bcl-XL and that apoptosis induction by 2,3-DCPE could be blocked by enforced overexpression of Bcl-XL. Our results suggest that 2,3-DCPE might be a potential new anticancer agent.

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results