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Your search keyword '"Rabizadeh S"' showing total 8 results
Start Over Author "Rabizadeh S" Journal cancer research
8 results on '"Rabizadeh S"'

1. Abstract P2-09-04: Identification of a neoantigen targeted by tumor-infiltrating lymphocytes in a patient with Her2+ breast cancer

Author

Reimann, H, primary, Nguyen, A, additional, Hübner, H, additional, Erber, R, additional, Bausenwein, J, additional, Van der Meijden, ED, additional, Lux, MP, additional, Jud, S, additional, Griffioen, M, additional, Rauh, C, additional, Sanborn, JZ, additional, Benz, SC, additional, Rabizadeh, S, additional, Beckmann, MW, additional, Mackensen, A, additional, Rübner, M, additional, Fasching, PA, additional, and Kremer, AN, additional

Published
2019
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2. Abstract P1-07-20: Developing prognostic indicators of poor outcomes in PRAEGNANT metastatic breast cancer cohort

Author

Szeto, C, primary, Benz, S, additional, Nguyen, A, additional, Rübner, M, additional, Wallwiener, D, additional, Tesch, H, additional, Hadji, P, additional, Fehm, TN, additional, Janni, W, additional, Overkamp, F, additional, Lueftner, D, additional, Lux, MP, additional, Wallwiener, M, additional, Beckmann, MW, additional, Huebner, H, additional, Ettl, J, additional, Hartkopf, AD, additional, Mueller, V, additional, Taran, FA, additional, Belleville, E, additional, Schneeweiss, A, additional, Soon-Shiong, P, additional, Rabizadeh, S, additional, and Fasching, PA, additional

Published
2018
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3. Abstract P2-02-16: Use of cell-free circulating RNA and expression of PD-L1 and HER2 in plasma to monitor and predict clinical response in metastatic breast cancer patients

Author

Castrellon, AB, primary, Velez, M, additional, Raez, LE, additional, Danenberg, K, additional, Rabizadeh, S, additional, Usher, J, additional, Jaimes, Y, additional, Hunis, B, additional, Bittencourt, AC, additional, Milillo, A, additional, Blaya, M, additional, Habaue, C, additional, and Danenberg, PV, additional

Published
2018
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6. Abstract P6-05-08: Integrating whole exome sequencing data with RNAseq and quantitative proteomics to better inform clinical treatment decisions in patients with metastatic triple negative breast cancer

Author

Soon-Shiong, P, primary, Rabizadeh, S, additional, Benz, S, additional, Cecchi, F, additional, Hembrough, T, additional, Mahen, E, additional, Burton, K, additional, Song, C, additional, Senecal, F, additional, Schmechel, S, additional, Pritchard, C, additional, Dorschner, M, additional, Blau, S, additional, and Blau, A, additional

Published
2016
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7. Abstract P6-04-14: Integrating whole genome sequencing data with RNAseq, pathway analysis, and quantitative proteomics to determine prognosis after standard adjuvant treatment with trastuzumab and chemotherapy in primary breast cancer patients

Author

Benz, SC, primary, Rabizadeh, S, additional, Cecchi, F, additional, Beckman, MW, additional, Brucker, SY, additional, Hartmann, A, additional, Golovato, J, additional, Hembrough, T, additional, Janni, W, additional, Rack, B, additional, Sanborn, JZ, additional, Schneeweiss, A, additional, Vaske, CJ, additional, Soon-Shiong, P, additional, and Fasching, PA, additional

Published
2016
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8. A monoclonal antibody that induces neuronal apoptosis binds a metastasis marker.

Author

Zhong LT, Manzi A, Skowronski E, Notterpek L, Fluharty AL, Faull KF, Masada I, Rabizadeh S, Varsanyi-Nagy M, Ruan Y, Oh JD, Butcher LL, and Bredesen DE

Subjects
Animals, Antibodies, Monoclonal immunology, Antibodies, Monoclonal pharmacology, Antigens, Surface immunology, Antigens, Surface isolation & purification, Apoptosis immunology, Carbohydrate Sequence, Cell Transformation, Neoplastic, Globosides immunology, Globosides isolation & purification, HeLa Cells, Humans, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Neurons immunology, Neurons metabolism, Signal Transduction physiology, Antibodies, Monoclonal metabolism, Antigens, Surface metabolism, Apoptosis physiology, Globosides metabolism, Neurons cytology
Abstract

The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the antibody, however, lacked the ability to induce cell death. The antigen was purified, and characterized by compositional analysis, fast atom bombardment (FAB) mass spectrometry, sequential exoglycosidase treatments, methylation analysis, and (1)H-nuclear magnetic resonance spectroscopy, proving to be isoglobotetraosylceramide (IsoGb4). IsoGb4 has been shown previously to be a metastasis marker, antibodies against which block metastases in a mammary adenocarcinoma model (S. A. Carlsen et al., Cancer Res., 53: 2906-2911, 1993). Addition of the purified antigen to cells lacking this glycolipid demonstrated that it is capable of functioning as a portable apoptosis-transducing molecule. Intracellular ceramide levels were increased after the treatment with the apoptosis-inducing antibody, but the membrane sphingomyelin level remained unchanged. Fumonisin B1 inhibited both the ceramide increase and the apoptosis induced via IsoGb4, which indicated that the ceramide synthase pathway is likely to be involved in apoptosis induction by IsoGb4.

Published
2001

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