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14 results on '"Skuli, Nicolas"'

1. Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma

Author

Riscal, Romain, primary, Gardner, Sarah M., additional, Coffey, Nathan J., additional, Carens, Madeleine, additional, Mesaros, Clementina, additional, Xu, Jimmy P., additional, Xue, Yizheng, additional, Davis, Leah, additional, Demczyszyn, Sara, additional, Vogt, Austin, additional, Olia, Adam, additional, Finan, Jennifer M., additional, Godfrey, Jason, additional, Schultz, David C., additional, Blair, Ian A., additional, Keith, Brian, additional, Marmorstein, Ronen, additional, Skuli, Nicolas, additional, and Simon, M. Celeste, additional

Published
2024
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2. Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis

Author

Liu, Ying, primary, Murazzi, Ileana, additional, Fuller, Ashley M., additional, Pan, Hehai, additional, Irizarry-Negron, Valerie M., additional, Devine, Ann, additional, Katti, Rohan, additional, Skuli, Nicolas, additional, Ciotti, Gabrielle E., additional, Pak, Koreana, additional, Pack, Michael A., additional, Simon, M. Celeste, additional, Weber, Kristy, additional, Cooper, Kumarasen, additional, and Eisinger-Mathason, T.S. Karin, additional

Published
2024
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3. Abstract PR010: In-“speck”-ting the nucleus: Nuclear speckles are a critical layer of gene regulation that predict outcomes in clear cell renal cell carcinoma

Author

Alexander, Katherine A., primary, Yu, Ruofan, additional, Faunce, Christine, additional, Skuli, Nicolas, additional, Coffey, Nathan, additional, Nguyen, Son, additional, Biddle, Nicholas, additional, Li, Catherine, additional, Joyce, Eric, additional, Raj, Arjun, additional, Simon, M. Celeste, additional, and Berger, Shelley, additional

Published
2023
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4. Abstract B008: Activation of the bile acid pathway promotes tumorigenesis in clear cell renal cell carcinoma

Author

Riscal, Romain, primary, Gardner, Sarah, additional, Carens, Madeleine, additional, Mesaros, Clementina, additional, Xu, Jimmy, additional, Coffey, Nate, additional, Davis, Leah, additional, Vogt, Austin, additional, Olia, Adam, additional, Finan, Jennifer, additional, Godfrey, Jason, additional, Blair, Ian, additional, Keith, Brian, additional, Marmorstein, Ronen, additional, Skuli, Nicolas, additional, and Simon, Celeste, additional

Published
2023
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5. Abstract B003: Increasing branched-chain amino acid metabolism reduces clear cell renal cell carcinoma growth

Author

Coffey, Nathan J., primary, Riscal, Romain, additional, Skuli, Nicolas, additional, Lesner, Nicholas P., additional, Noji, Michael, additional, Jiang, Christine, additional, Kim, Laura C., additional, Han, Xu, additional, Blair, Megan C., additional, Keith, Brian, additional, Arany, Zoltan, additional, and Simon, M. Celeste, additional

Published
2023
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6. Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma

Author

Anderson, Nicole M., primary, Qin, Xiaodan, additional, Finan, Jennifer M., additional, Lam, Andrew, additional, Athoe, Jacob, additional, Missiaen, Rindert, additional, Skuli, Nicolas, additional, Kennedy, Annie, additional, Saini, Amandeep S., additional, Tao, Ting, additional, Zhu, Shizhen, additional, Nissim, Itzhak, additional, Look, A. Thomas, additional, Qing, Guoliang, additional, Simon, M. Celeste, additional, and Feng, Hui, additional

Published
2021
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7. Abstract 6268: Use of the anti-viral drug ribavirin as a radiosensitizing agent in nasopharyngeal carcinoma

Author

Huq, Sakibul, primary, Casaos, Joshua, additional, Serra, Riccardo, additional, Peters, Michael, additional, Xia, Yuanxuan, additional, Ding, Andy, additional, Ehresman, Jeffrey, additional, Kedda, Jayanidhi, additional, Morales, Manuel, additional, Gorelick, Noah, additional, Zhao, Tianna, additional, Ishida, Wataru, additional, Perdomo-Pantoja, Alexander, additional, Cecia, Arba, additional, Ji, Chenchen, additional, Suk, Ian, additional, Sidransky, David, additional, Brait, Mariana, additional, Brem, Henry, additional, Skuli, Nicolas, additional, and Tyler, Betty, additional

Published
2020
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10. Abstract A41: Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis

Author

Eisinger-Mathason, T.S. Karin, primary, Zhang, Minsi, additional, Qiong, Qiu, additional, Skuli, Nicolas, additional, Nakazawa, Michael S., additional, Karakasheva, Tatiana, additional, Mucaj, Vera, additional, Shay, Jessica E.S., additional, Stangenberg, Lars, additional, Pure, Ellen, additional, Yoon, Sam S., additional, Kirsch, David G., additional, and Simon, M. Celeste, additional

Published
2015
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14. Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma.

Author

Skuli N, Monferran S, Delmas C, Favre G, Bonnet J, Toulas C, and Cohen-Jonathan Moyal E

Subjects
Animals, Cell Adhesion physiology, Cell Hypoxia physiology, Cell Line, Tumor, Focal Adhesion Protein-Tyrosine Kinases antagonists & inhibitors, Glioblastoma enzymology, Glioblastoma genetics, Glioblastoma pathology, Humans, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Integrin alphaVbeta3 antagonists & inhibitors, Mice, Protein Serine-Threonine Kinases metabolism, Receptors, Vitronectin antagonists & inhibitors, Signal Transduction, Transfection, Transplantation, Heterologous, Focal Adhesion Protein-Tyrosine Kinases metabolism, Glioblastoma metabolism, Integrin alphaVbeta3 metabolism, Oxygen metabolism, Receptors, Vitronectin metabolism, rhoB GTP-Binding Protein metabolism
Abstract

The presence of hypoxic areas in glioblastoma is an important determinant in tumor response to therapy and, in particular, to radiotherapy. Here we have explored the involvement of integrins, up to now known as regulators of angiogenesis and invasion, in the regulation of tumor hypoxia driven from the tumor cell. We first show that hypoxia induces the recruitment of alpha(v)beta(3) and alpha(v)beta(5) integrins to the cellular membrane of U87 and SF763 glioblastoma cells, thereby activating the focal adhesion kinase (FAK). We then show that inhibiting alpha(v)beta(3) or alpha(v)beta(5) integrins in hypoxic cells with a specific inhibitor or with siRNA decreases the hypoxia-inducible factor 1alpha (HIF-1alpha) intracellular level. This integrin-dependent regulation of HIF-1alpha is mediated through the regulation of FAK, which in turn activates the small GTPase RhoB, leading to the inhibition of GSK3-beta. Furthermore, silencing this pathway in glioma cells of established xenografts dramatically reduces glioma hypoxia, associated with a significant decrease in vessel density. Our present results unravel a new mechanism of hypoxia regulation by establishing the existence of an alpha(v)beta(3)/alpha(v)beta(5) integrin-dependent loop of hypoxia autoregulation in glioma. Targeting this hypoxia loop may be crucial to optimizing radiotherapy efficiency.

Published
2009
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