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Your search keyword '"Yeung, Sai-Ching J."' showing total 6 results
Start Over Author "Yeung, Sai-Ching J." Journal cancer research
6 results on '"Yeung, Sai-Ching J."'

1. Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors

Author

Bankson, James A., primary, Walker, Christopher M., additional, Ramirez, Marc S., additional, Stefan, Wolfgang, additional, Fuentes, David, additional, Merritt, Matthew E., additional, Lee, Jaehyuk, additional, Sandulache, Vlad C., additional, Chen, Yunyun, additional, Phan, Liem, additional, Chou, Ping-Chieh, additional, Rao, Arvind, additional, Yeung, Sai-Ching J., additional, Lee, Mong-Hong, additional, Schellingerhout, Dawid, additional, Conrad, Charles A., additional, Malloy, Craig, additional, Sherry, A. Dean, additional, Lai, Stephen Y., additional, and Hazle, John D., additional

Published
2015
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2. Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma

Author

Phan, Liem M., primary, Fuentes-Mattei, Enrique, additional, Wu, Weixin, additional, Velazquez-Torres, Guermarie, additional, Sircar, Kanishka, additional, Wood, Christopher G., additional, Hai, Tao, additional, Jimenez, Camilo, additional, Cote, Gilbert J., additional, Ozsari, Levent, additional, Hofmann, Marie-Claude, additional, Zheng, Siyuan, additional, Verhaak, Roeland, additional, Pagliaro, Lance, additional, Cortez, Maria Angelica, additional, Lee, Mong-Hong, additional, Yeung, Sai-Ching J., additional, and Habra, Mouhammed Amir, additional

Published
2015
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3. Abstract 3927: Obesity induces changes in adipokines profile and activates Akt/mTOR signaling accelerating breast carcinogenesis and tumor growth

Author

Fuentes-Mattei, Enrique, primary, Velazquez-Torres, Guermarie, additional, Phan, Liem, additional, Zhang, Fanmao, additional, Chou, Ping-Chieh, additional, Shin, Ji-Hyun, additional, Choi, Hyun-Ho, additional, Chen, Jiun-Sheng, additional, Zhao, Ruiying, additional, Chen, Jian, additional, Gully, Chris, additional, Carlock, Colin, additional, Qi, Yuan, additional, Zhang, Ya, additional, Wu, Yun, additional, Esteva, Francisco, additional, Luo, Yongde, additional, McKeehan, Wallace L., additional, Ensor, Joe E., additional, Hortobagyi, Gabriel N., additional, Pusztai, Lajos Pusztai, additional, Symmans, W. Fraser, additional, Lee, Mong-Hong, additional, and Yeung, Sai-Ching J., additional

Published
2014
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4. Abstract LB-283: Aurora B binds p53 during both interphase and mitosis, phosphorylates it and promotes its degradation

Author

Fuentes-Mattei, Enrique, primary, Gully, Christopher, additional, Velazquez-Torres, Guermarie, additional, Shin, Ji-Hyun, additional, Chen, Jiun-Sheng, additional, Choi, Hyun Ho, additional, Chou, Ping-Chieh, additional, Adams, Henry P., additional, Phan, Liem, additional, Yang, Tsung-Ying, additional, Yeung, Sai-Ching J., additional, and Lee, Mong-Hong, additional

Published
2012
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6. Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.

Author

Bankson, James A., Walker, Christopher M., Ramirez, Marc S., Stefan, Wolfgang, Fuentes, David, Merritt, Matthew E., Jaehyuk Lee, Sandulache, Vlad C., Yunyun Chen, Liem Phan, Ping-Chieh Chou, Rao, Arvind, Yeung, Sai-Ching J., Mong-Hong Lee, Schellingerhout, Dawid, Conrad, Charles A., Malloy, Craig, Sherry, A. Dean, Lai, Stephen Y., and Hazle, John D.

Subjects
*HYPERPOLARIZATION (Cytology), *PYRUVATES, *METABOLITES, *PERFUSION, *PHARMACOKINETICS
Abstract

Hyperpolarized 1-13C-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are highly transient and their spatial distribution varies continuously over their observable lifetime. Therefore, new imaging approaches are needed to ensure optimal measurement under these circumstances. Constrained reconstruction algorithms can integrate prior information, including biophysical models of the substrate/target interaction, to reduce the amount of data that is required for image analysis and reconstruction. In this study, we show that metabolic MRI with hyperpolarized pyruvate is biased by tumor perfusion, and present a new pharmacokinetic model for hyperpolarized substrates that accounts for these effects. The suitability of this model is confirmed by statistical comparison to alternates using data from 55 dynamic spectroscopic measurements in normal animals and murine models of anaplastic thyroid cancer, glioblastoma, and triple-negative breast cancer. The kinetic model was then integrated into a constrained reconstruction algorithm and feasibility was tested using significantly under-sampled imaging data from tumor-bearing animals. Compared to naïve image reconstruction, this approach requires far fewer signal-depleting excitations and focuses analysis and reconstruction on new information that is uniquely available from hyperpolarized pyruvate and its metabolites, thus improving the reproducibility and accuracy of metabolic imaging measurements. [ABSTRACT FROM AUTHOR]

Published
2015
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