1. A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients
- Author
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Akira Inoue, Yuichi Takiguchi, Ikuo Sekine, Isamu Okamoto, Ichiro Yoshino, Takehito Shukuya, Etsuo Miyaoka, Katsuyuki Kiura, Yasushi Shintani, Meinoshin Okumura, Hirotoshi Dosaka-Akita, Kazuhisa Takahashi, and Koichi Takayama
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Palliative care ,Demographics ,medicine.medical_treatment ,Registry study ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,non–small cell lung cancer ,Clinical Research ,Internal medicine ,tyrosine kinase inhibitors ,medicine ,Stage (cooking) ,Lung cancer ,Survival rate ,Chemotherapy ,TNM stage ,business.industry ,General Medicine ,Original Articles ,medicine.disease ,respiratory tract diseases ,030104 developmental biology ,Oncology ,Treatment modality ,030220 oncology & carcinogenesis ,Original Article ,small cell lung cancer ,business ,epidermal growth factor receptor - Abstract
This study provides the benchmark statistics on medically treated patients with non–small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) in Japan. Demographic background, treatment, and prognosis were obtained from patients with lung cancer pathologically diagnosed in 2012, who received nonsurgical treatment. Descriptive statistics and their associations with survival were analyzed. In total, 12 320 patients were registered from 314 institutions in Japan. The median age was 70 years, and 73% of the patients were male. The number (%) of stages I, II, III, and IV diseases were 468 (3.8%), 421 (3.4%), 3260 (26.5%), and 8171 (66.3%), respectively. NSCLC and SCLC accounted for 9872 (80.1%) and 2353 (19.1%) patients, respectively. Thoracic radiotherapy‐based therapy, chemotherapy, and palliative care alone were administered to 2572 (20.9%), 7790 (63.2%), and 1952 (15.8%) patients, respectively. Clinical TNM stage was one of the strongest prognostic factors with the 3‐year survival rates of 62.9%, 47.3%, 40.0%, 27.8%, 37.5%, 26.5%, and 18.2% for stages IA, IB, IIA, IIB, IIIA, IIIB, and IV, respectively. Among 6158 patients with NSCLC treated with chemotherapy, the 3‐year survival rate was 33.4% in patients receiving epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs) at some point in their clinical course, whereas it was 17.4% in patients who did not. The 3‐year survival rate of SCLC was only 15.9%. In conclusion, approximately two‐thirds of the patients were diagnosed as stage IV at the initial diagnosis. Use of EGFR‐TKIs significantly improved the survival of patients with NSCLC., This study provides the benchmark statistics on medically treated patients with lung cancer in Japan. Here, 3‐year survival rates of patients treated with concurrent chemoradiotherapy (n = 1689), sequential chemoradiotherapy (n = 221), thoracic radiotherapy alone (n = 662), chemotherapy alone (n = 7790) and palliative care alone (n = 1952) were 43.6%, 29.1%, 40.0%, 19.9%, and 0.3.4%, respectively.
- Published
- 2020