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The article from Cancer Weekly discusses the role of the tumor suppressor FBXW7 in alleviating c-MYC repression of pyruvate carboxylase to support metabolic flexibility in mammalian cells. The study combines nutrient and genome-wide CRISPR/Cas9 screening to map signaling and metabolic pathways that aid cell proliferation in glutamine-limited conditions. The research sheds light on the molecular mechanisms underlying metabolic flexibility and the pathways involved in glutamine dependency, which is a characteristic of several cancers. [Extracted from the article]

A study conducted by the Chinese Academy of Sciences in Chengdu, China, focused on designing and synthesizing novel erianin analogues as pyruvate carboxylase (PC) inhibitors in hepatocellular carcinoma cells. The researchers found that two fluorinated compounds, 35 and 36, exhibited higher activity than erianin in liver cancer cells. These compounds also showed better chemical stability and may be potential candidates for further drug development. The study provides insights into the structure-activity relationship of these analogues and their potential use in treating liver cancer. [Extracted from the article]

The University of Minnesota has been issued a patent for a method to improve the development of chimeras through hiPSC engineering and embryo aggregation. The patent explains how human cells can be introduced into non-human embryos and cultured before transfer to increase the efficiency of generating human:non-human animal chimeras. The inventors also suggest disrupting specific genes in the non-human embryos to enhance chimera generation. The patent acknowledges the challenges and costs associated with creating chimeric animals using human pluripotent stem cells and aims to improve the success rate of chimera generation for various applications in genetics and engineering. For more information, please refer to the full patent. [Extracted from the article]

Reports on Prostate Cancer Findings from Southern Medical University Provide New Insights (Acetyl-coa Carboxylase 1 Depletion Suppresses De Novo Fatty Acid Synthesis and Mitochondrial ? Keywords: Guangzhou; People's Republic of China; Asia; Acetyl-CoA Carboxylase; Cancer; Carbon-Carbon Ligases; Carboxylase; Enzymes and Coenzymes; Health and Medicine; Oncology; Prostate Cancer; Prostatic Neoplasms EN Guangzhou People's Republic of China Asia Acetyl-CoA Carboxylase Cancer Carbon-Carbon Ligases Carboxylase Enzymes and Coenzymes Health and Medicine Oncology Prostate Cancer Prostatic Neoplasms 808 808 1 03/23/23 20230321 NES 230321 2023 MAR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on Oncology - Prostate Cancer are presented in a new report. Guangzhou, People's Republic of China, Asia, Cancer, Carbon-Carbon Ligases, Carboxylase, Enzymes and Coenzymes, Health and Medicine, Oncology, Prostate Cancer, Prostatic Neoplasms, Acetyl-CoA Carboxylase. [Extracted from the article]