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A recent study conducted at University College Dublin focused on the uptake of cervical screening and the acceptability of HPV self-sampling among Irish Traveller women, a minority ethnic group facing health disparities. The research found that while 75.3% of eligible Traveller women received invitations for screening, only 68% attended at least once, with 20.2% finding HPV self-sampling acceptable. The study suggests that barriers to accessing mainstream health services may contribute to lower screening rates, and highlights the potential of HPV self-sampling to improve cervical screening rates among Traveller women. [Extracted from the article]

A study conducted in Poznan, Poland, focused on cervical intraepithelial neoplasia, highlighting the prevalence of human papillomavirus (HPV) in the population and its association with cervical cancer. The research compared the effectiveness of an In Situ Hybridization (ISH) assay with PCR assays in detecting HPV DNA in cervical tissue specimens. The findings suggested that automatic signal detection of ISH assay may not be the most suitable method for cervical tissue material, and recommended HPV testing with genotyping for a more comprehensive approach. The study emphasized the importance of interpreting ISH test results in the context of clinical history and morphology. [Extracted from the article]

The article discusses a study that aims to identify tissue-specific mutational patterns associated with cancer development by leveraging clustering analysis. The study constructed a Network Graph of 8303 patients and 198 genes from single-point-mutation data retrieved from The Cancer Genome Atlas (TCGA). The analysis revealed 42 mutational patterns not reported in previous TCGA consortium publications, including findings related to colon and rectal adenocarcinomas, head and neck squamous cell carcinoma, and genetic alterations within mutational-based clusters. This preprint has not been peer-reviewed and more information can be found at biorxiv.org/content/10.1101/2024.02.26.582027v4. [Extracted from the article]

A recent report from the N.N. Blokhin National Medical Research Center of Oncology highlights the prevalence of breast, prostate, lung, and colorectal carcinomas in global cancer incidence and mortality rankings. The study examines the potential connection between these cancers and oncogenic human papillomaviruses (HPVs), with findings suggesting that HPVs may be risk factors for these types of carcinomas. The research emphasizes the importance of further investigation into the role of oncogenic HPVs in these common forms of cancer. [Extracted from the article]

A recent study conducted in Maharashtra, India, focused on the association of oral cancer with addiction and sociodemographic characteristics. The research found that oral cancer is a significant health issue in India, with primary risk factors including alcohol consumption, tobacco usage, betelnut chewing, and HPV infection. The study, involving 233 oral cancer patients, highlighted that males above 60 and females aged 41-50 were the most affected groups, with the cheek and tongue being the primary sites for oral cancer. The researchers emphasized the importance of public education and health promotion strategies to reduce smoking and alcohol consumption in order to address the increasing prevalence of oral cancer in India. [Extracted from the article]

Biogenes Technologies has launched the world's first aptamer-based histochemistry staining kit for HPV, targeting the E6 oncoprotein of HPV16. This product offers a more stable and consistent alternative to antibody-based products, with better performance and lower cost. Biogenes aims to improve access to HPV diagnosis, especially in low and middle-income countries, and is working on developing an on-demand platform for various cancer diagnoses using aptamers. [Extracted from the article]

A recent report from the University of California San Francisco (UCSF) highlights the association between CYLD alterations and metastasis in Human Papilloma Virus-positive Head and Neck Cancer (HNSCC). The study found that patients with CYLD alterations had a poorer prognosis and increased metastasis compared to those with wild-type CYLD. This research sheds light on the role of CYLD mutations in disease progression and overall survival in HPV-positive HNSCC patients. [Extracted from the article]

The research from Tufts University School of Medicine delves into the essential determinants of human papillomavirus (HPV) carcinogenesis, highlighting the role of HPV E6 and E7 proteins in driving HPV-associated cancers. The study emphasizes the need to identify critical drivers of HPV carcinogenesis to develop targeted anti-cancer therapies. This research provides valuable insights into the molecular mechanisms underlying HPV infections and their link to cancer development. [Extracted from the article]

A recent study conducted at Afe Babalola University focused on investigating mutational signatures p53 and RB in human papilloma virus-associated squamous cell carcinoma of the cervix. The research utilized nucleic acid amplification techniques and DNA sequencing to analyze mutations in the RB and p53 genes. The study concluded that inactivation of tumor-suppressor proteins RB and p53 plays a crucial role in cervical carcinogenesis, either through mutation or complex formation with HPV oncoproteins. This research provides valuable insights into the genetic mechanisms underlying squamous cell carcinoma development in the cervix. [Extracted from the article]

A study conducted at Christian Medical College in Tamil Nadu, India, focused on imaging descriptors of Human Papilloma Virus (HPV)-mediated and HPV-negative oropharyngeal cancers in Indian subcontinental patients. The research found no statistically significant imaging differences between the two types of malignancies, with the only notable epidemiological difference being that HPV-mediated malignancies were more common in women and nonsmokers. The study suggests the need for further research to determine if the downstaging of treatment and better prognosis associated with HPV-mediated malignancies in Western populations also apply to the Indian subcontinent. [Extracted from the article]

A recent study conducted at the University of Palermo in Italy compared two non-invasive sampling methods, oral rinse and oral sponge, for detecting Human Papillomavirus (HPV) DNA in patients with oral squamous cell carcinoma (OSCC). The study found that oral sponge sampling showed high specificity (100%), sensitivity (85.7%), and accuracy (96.2%) compared to oral rinse sampling. The researchers concluded that oral sponge sampling could be a valuable non-invasive alternative for HPV detection in OSCC patients, especially for those who may have functional deficits due to the disease. Further research is recommended to validate these findings and explore the integration of these methods into routine clinical practice for managing HPV-related OSCC. [Extracted from the article]

A new study conducted at the Memorial Sloan-Kettering Cancer Center in New York City has examined the pathologic features and outcomes of human papillomavirus (HPV)-associated oral cavity squamous cell carcinoma (OCSCC). The study found that HPV positivity in OCSCC was relatively low, occurring in 0.7% of cases in the Memorial Sloan-Kettering cohort and 4.9% in The Cancer Genomic Atlas program cohort. The study also found that HPV-positive OCSCC predominantly affected male patients and smokers, and could occur in various locations within the oral cavity. However, HPV positivity did not appear to affect outcomes such as disease-specific survival and progression-free survival in OCSCC. [Extracted from the article]

A recent study conducted by researchers at the University of Chile has found a positive relationship between the presence of human papillomavirus (HPV) and the upregulation of the cIAP2 protein in oropharyngeal cancers (OPCs). The study also revealed that cIAP2 promotes radioresistance, which is a concern in the treatment of head and neck cancers (HNCs). The researchers determined the expression of cIAP2 in 49 OPCs from Chilean patients and found a statistically significant association between HPV presence and cIAP2 expression. Additionally, knocking down cIAP2 in HPV-driven HNC cells increased their sensitivity to radiation-induced apoptosis, suggesting that cIAP2 could be a potential therapeutic target for radiation in HPV-driven HNC. [Extracted from the article]

A systematic review conducted by researchers at Servico de Pneumologia in Lisbon, Portugal explores the diagnostic criteria, epidemiology, etiology, and prognosis of Human Papillomavirus (HPV) infection in lung cancer. The review analyzed 97 studies encompassing 9098 patients worldwide and found varied HPV infection rates in lung cancer, ranging from 0% to 69%. While the association between HPV16/18 and lung cancer remained inconclusive, intriguing associations were noted, including HPV's potential role in lung adenocarcinoma and squamous cell carcinoma. The review concludes that further research with standardized methodologies and larger cohorts is needed to clarify HPV's role in lung cancer. [Extracted from the article]

Asieris Pharmaceuticals has published data from a Phase III clinical study on its non-surgical treatment candidate, Cevira (APL-1702), for cervical High-Grade Squamous Intraepithelial Lesion (HSIL). The study focused on the analysis of different age subgroups and found that the APL-1702 group showed an increase in the pathological regression rate compared to the placebo control group in the age groups of 20-30 years and 30-40 years. Additionally, the APL-1702 group demonstrated enhancements in HPV clearance rates compared to the placebo control group in the 20-30 years age group. The study suggests that APL-1702 has significant therapeutic potential for the HSIL population aged 20-40 years. [Extracted from the article]

According to a preprint abstract from biorxiv.org, fibroblasts play a role in regulating the transformation potential of human papillomavirus (HPV)-positive keratinocytes. While persistent HPV infection is necessary for viral oncogenesis, additional factors such as immune evasion and viral integration contribute to HPV-induced cancer progression. It is widely accepted that HPV-positive keratinocytes require co-culture with fibroblasts to maintain viral episome expression, but the exact mechanisms for this are still unknown. Comprehensive RNA sequencing and proteomic analysis have provided insights into the role of fibroblasts in HPV-related transformation mechanisms. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A recent study conducted by researchers from the National Cancer Institute (NCI) has explored the molecular landscape of invasive cervical cancers (ICC) caused by HPV infections. The study investigated the detection, timing, and specificity of somatic mutations in HPV-positive cervical cell samples. The researchers discovered a subset of hotspot mutations that were more prevalent in precancerous lesions and cancers, particularly glandular precancer lesions. The findings suggest that these mutations may be involved in ICC carcinogenesis and could potentially serve as diagnostic biomarkers. The study demonstrates the feasibility of using exfoliated cervical cells for the detection of somatic mutations. [Extracted from the article]

A new study conducted by researchers at the University of New South Wales Sydney explores the use of self-collected anal swabs for anal cancer screening. The study found that self-collected swabs were comparable to clinician-collected swabs in terms of HPV testing adequacy, but slightly lower in cytology testing adequacy. There was no significant difference in prevalence of HPV or cytological abnormalities between the two methods. However, larger studies are needed to further assess the use of self-collected swabs in anal cancer screening programs. [Extracted from the article]

A recent study conducted in Taiwan has found a significant link between Human Papillomavirus (HPV) infection and an increased risk of colorectal cancer (CRC). The study analyzed population datasets from 2007 to 2017 and found that HPV-positive patients had a considerably higher risk of CRC compared to non-infected individuals. The risk was higher in males than females, and increased with advancing age. The study also revealed varying risks for different anatomical locations, with the anus having the highest risk. Comorbid conditions such as hypertension, diabetes mellitus, and abnormal liver function were also found to correlate with increased CRC risks. These findings highlight the need for intervention strategies and targeted prevention for individuals at risk. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the relationship between human papillomavirus (HPV) integration and genomic instability in tonsillar keratinocytes. The study found that tumors with integrated HPV exhibit greater genomic instability compared to those with only episomal viral genomes. However, the integration of the virus does not cause genomic instability, but rather promotes it. Additionally, cell lines with integrated HPV were found to be more tumorigenic than those with episomal HPV. This research provides insights into the role of viral integration and genomic instability in HPV-associated oropharyngeal squamous carcinomas. [Extracted from the article]

A study conducted at the University of California Irvine examined the use of hypofractionated radiation therapy alone for human papillomavirus (HPV)-positive oropharyngeal cancer. The study included 101 patients who were treated with radiation therapy alone using specific regimens. The results showed that the treatment resulted in excellent outcomes, with high rates of overall survival and local-regional control. The study also mentioned an ongoing clinical trial investigating this treatment modality in the context of de-escalation. [Extracted from the article]

According to a preprint abstract, researchers have developed a deep learning framework to predict the consensus molecular subtypes (CMS) of HPV-positive cervical squamous cell carcinoma (CSCC) patients using routine histology images. The study analyzed three international CSCC cohorts and found that the CMS can be accurately predicted from histology slides, with significant implications for patient stratification and survival. The researchers also discovered distinct differences in the tumor microenvironment between the CMS subtypes, providing insights into potential therapeutic targets. This study introduces a Digital-CMS score that could be used as a clinical tool and identifies histological patterns as potential surrogate markers for the CMS subtypes. [Extracted from the article]

A new report published in Cancer Weekly discusses the risk factors for anal cancer in solid organ transplant recipients. The study found that solid organ transplantation is a risk predictor for anal squamous intraepithelial lesions and cancer. The prevalence of anal cancer among transplant recipients was found to be equal to that of the general population. The researchers recommend targeted anal screenings for higher-risk subsets, such as female recipients farther out from transplant and patients with genitourinary HPV-related diseases. [Extracted from the article]

A recent study conducted by researchers at the University of Texas MD Anderson Cancer Center explored the association between human papillomavirus (HPV) genotype and phylogenic clade with oropharyngeal cancer outcomes. The study found that non-HPV16 genotype and A7 clade were associated with worse overall survival (OS) in patients with M0 disease treated with curative intent. However, when adjusting for patient and tumor covariates, neither HPV genotype nor phylogenic clade were prognostic, suggesting that differences in outcomes may be related to distinct clinical profiles rather than inherent viral properties. This research provides valuable insights into the impact of specific HPV genotypes on patient outcomes and has implications for treatment de-intensification. [Extracted from the article]

A recent systematic review conducted by researchers from University Hospital in Mostar, Bosnia and Herzegovina, explored the impact of Human Papillomavirus (HPV) on microRNA-21 (miR-21) expression in oral and oropharyngeal cancer. The review analyzed four studies with a total sample size of 621 subjects with oral and/or oropharyngeal squamous cell carcinoma (OSCC/OPSCC). The findings indicated that there were no significant differences in miR-21 expression between HPV-positive and HPV-negative OSCC/OPSCC. However, the researchers noted that more studies are needed to better understand the molecular mechanisms underlying the development and progression of OSCC/OPSCC influenced by HPV and miR-21 expression. [Extracted from the article]

A recent report from the University of Rijeka in Croatia discusses the increasing prevalence of Human Papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC), particularly oropharyngeal squamous cell carcinoma (OPSCC), worldwide. The report highlights the importance of accurately diagnosing HPV in HNSCC and personalizing treatment strategies. The combination of p16 immunohistochemistry (IHC) and polymerase chain reaction (PCR) is recommended for diagnosing HPV, with advanced techniques like next-generation sequencing (NGS) and RNA-based assays providing further insights. The report also explores various HPV detection techniques, biomarkers, and emerging technologies in the field. [Extracted from the article]

A recent study conducted at Sun Yat-sen University Cancer Center explored the effectiveness of transoral robotic surgery (TORS) compared to traditional surgery in treating oropharyngeal cancer (OPC) patients. The study found that TORS exhibited a superior prognosis for OPC patients, particularly those with a T1-T2 classification and stages I-II or III-IV. Additionally, the study identified specific single-nucleotide variations (SNVs) in the HPV16 genome that were associated with worse survival in HPV-positive OPC patients. These findings have important implications for treatment decision-making and prognostic assessment in patients with OPC. [Extracted from the article]

Researchers at the University of California San Francisco (UCSF) have conducted a study on anal cancer in men who have sex with men (MSM) with HIV. The study aimed to determine if there are differences in the microbiome of the anal canal compared to stool samples, and if changes in the anal microbiome are associated with high-grade squamous intraepithelial lesions (HSIL), a precursor to anal cancer. The researchers found distinct differences in the anal microbiome between MSM with HSIL and those without, with pro-inflammatory and carcinogenic species being more prevalent in MSM with HSIL. This research suggests that a pro-inflammatory and carcinogenic environment may be associated with anal HSIL. [Extracted from the article]

A recent study conducted by researchers at the University of Opole in Poland explored the relationship between telomere length, telomerase activity, and the vaginal microbiome in patients with HPV-related precancerous lesions. The study found significant differences in telomere length and telomerase expression between different histopathology groups, with lower telomere length observed in carriers of HPV. The highest levels of telomerase expression were found in the high-grade squamous intraepithelial lesion (H SIL) group. The study suggests that combining HPV infection identification, telomere length assessment, and telomerase expression measurement may be more predictive than conducting these analyses separately. [Extracted from the article]

A recent study conducted by researchers at the Autonomous University of Guerrero explores the role of high-risk human papillomavirus (HR-HPV) integration in the progression of premalignant lesions into different types of cancer. The study highlights the association between HR-HPV and various types of cancer, including cervical, head and neck, vulvar, vaginal, penile, and anal cancers. Factors such as viral genotype, infection with multiple viruses, viral load, viral persistence, and type of integration play a crucial role in determining the sites at which the virus integrates into the host cell genome, leading to the loss of function of tumor suppressor genes and increased oncogene expression. The purpose of this review is to identify common factors associated with the role of integration events in the progression of premalignant lesions in different types of cancer. [Extracted from the article]

Researchers from Kingston University London have discovered a unique case of concurrent high-risk HPV35, HPV45, and HPV59 infections in both prostate and bladder cancer tissues of a single patient. This is the first documented instance worldwide with identical HPV types detected in two adjacent organs of the same individual. The study highlights the potential intra-organ spread of HPV and the need for further investigation of alternative transmission routes. The findings offer new insights into the complex dynamics of HPV transmission in cancer pathogenesis. [Extracted from the article]

Researchers from the Massachusetts General Hospital Research Institute have developed a new method for on-site detection of nucleic acids (NA) using CRISPR and digital signal processing. This technology is particularly important for cervical cancer screening, as it provides a rapid and affordable alternative to current NA tests. The CreDiT platform allows for the sensitive detection of human papillomavirus (HPV) DNA targets and accurate identification of HPV types in clinical samples. This research has the potential to address the global disparity in cancer care, especially in low- and middle-income countries. [Extracted from the article]

A recent report from the University of Rijeka in Croatia discusses the role of biomarkers in head and neck cancer, specifically focusing on HPV-positive squamous cell carcinoma. The study highlights the changing landscape of head and neck cancer, with HPV infection becoming a major risk factor, particularly among nonsmokers. The researchers emphasize the importance of accurately diagnosing HPV-positive HNSCC in order to develop targeted treatment strategies and improve patient outcomes. The report also summarizes the current advancements in identifying biomarkers for non-invasive cancer diagnosis, monitoring, and assessment of therapeutic responses. [Extracted from the article]

A recent preprint abstract suggests that alterations in the PI3K pathway, a major intracellular regulatory pathway involved in cancer, may impact the response to immune checkpoint inhibitors in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC). The study found that PI3K pathway alterations were present in 44% of patients and were associated with poor clinical outcomes. Additionally, the activation of the PI3K pathway was found to promote an immune suppressive phenotype and confer resistance to immune checkpoint inhibitors in the HPV-negative subset of HNSCC patients. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]

A recent report discusses research on the potential use of nanoemulsions in cervical cancer therapy. The study focuses on cordialin A, a compound derived from Varronia curassavica Jacq. leaves, which has shown antitumor activity. The researchers encapsulated cordialin A in a nanoemulsion system and found that it exhibited enhanced cytotoxic effects on cervical tumor cells compared to free cordialin A. The study suggests that cordialin A-loaded nanoemulsion has potential as a treatment for cervical cancer. The research was conducted by Sao Paulo State University (UNESP) and was supported by various organizations. [Extracted from the article]

A recent study conducted by researchers at Johns Hopkins University examined the epidemiologic trends in human papillomavirus (HPV)-associated sinonasal squamous cell carcinoma (SNSCC). The study analyzed patient data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program database between 1975 and 2018. The findings showed that the proportion of HPV-associated SNSCC increased over time, with a rise in nasal cavity SNSCC and a decrease in HPV-independent maxillary sinus SNSCC. Patients with HPV-associated SNSCC had a higher 5-year overall survival rate compared to those with HPV-independent SNSCC. These results suggest that HPV-associated SNSCC has distinct demographic and prognostic characteristics. [Extracted from the article]

A recent study conducted by researchers at the Ruder Boskovic Institute in Zagreb, Croatia, explored the expression levels of three proteins in relation to the survival of patients with head and neck cancers. The study focused on the influence of these proteins on the prognosis of patients treated by primary surgery. The results showed that moderate levels of SCRIB, one of the proteins studied, were associated with worse prognosis in patients regardless of their human papillomavirus (HPV) status. The researchers concluded that further studies are needed to better understand the relationship between SCRIB levels and survival, particularly in Western populations where smoking and alcohol consumption are more prevalent. [Extracted from the article]

Researchers at Prince of Songkla University conducted a retrospective cohort study to examine the association between human papillomavirus (HPV) infection and overall survival rate in patients with oral cancer. The study included 454 patients with oral squamous cell carcinoma (OSCC), and the prevalence of HPV-positive status among these patients was found to be 10.2%. However, no significant association was found between HPV-positive status and 3-year overall survival in patients with oral cancer. This research provides valuable insights into the impact of HPV on survival in patients with oral cancer. [Extracted from the article]

A new study conducted by researchers at Chung Shan Medical University in Taiwan has found a significant increase in the risk of skin cancer, particularly squamous cell carcinoma (SCC), basal cell carcinoma, and melanoma, among individuals with human papillomavirus (HPV) infection. The study analyzed data from the National Health Insurance Research Database between 2007 and 2015 and revealed regional variations in skin cancer risk, with higher risks observed in southern Taiwan and the Kaohsiung-Pingtung area. The findings highlight the importance of sun protection, especially in regions with high UV exposure, and emphasize the need for preventive strategies in public health. [Extracted from the article]

A recent study conducted by researchers at Albert Einstein College of Medicine focused on the structure and transcription of integrated HPV DNA in vulvar carcinomas. The study found that HPV DNA was detected in five out of thirteen vulvar cancers, with HPV16 DNA being integrated into human DNA in three of those cases. The integrated viral DNA segments retained intact regulatory regions and oncogenes, and RNA sequencing revealed consistent transcription of the E7 and E6I genes. The study also found that HPV-positive and HPV-negative vulvar cancers exhibited different gene expression patterns, particularly in genes related to immune system function. The research highlights the importance of hybridization capture and DNA sequencing in identifying various HPV types, determining the integration status of viral DNAs, and understanding their structures. [Extracted from the article]

A recent report from the National Cancer Institute (NCI) discusses the relationship between Human Papillomavirus (HPV) and cancer. The report highlights the role of microhomology-mediated repair machinery in HPV integration and oncogenesis. The researchers provide a comprehensive review of the mechanisms underlying microhomology-mediated repair and its involvement in HPV integration in cancer. The report also discusses the implications of these processes on the lifecycles of other DNA viruses and the host's innate immune response. The research was supported by the NIH National Cancer Institute (NCI) and has been peer-reviewed. [Extracted from the article]

A recent study conducted by researchers at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, has found that the expression of a protein called cytokeratin-17 (K17) is commonly observed in skin tumors and plays a role in controlling viral protein synthesis. The researchers discovered that K17 expression is not directly linked to viral oncoprotein expression, but rather is associated with epithelial differentiation. The absence of K17 in tumor tissue was found to increase markers of cancer stem-like cells and negatively affect viral protein synthesis. These findings suggest that K17 may be an important regulator of epithelial differentiation and could potentially impact the development of skin tumors. [Extracted from the article]

A study conducted at Stanford University in California has explored the use of scattering-based light-sheet microscopy (sLSM) for the detection of human papillomavirus-associated squamous lesions of the anal canal. The researchers imaged 110 anal biopsy specimens and found that the sLSM images accurately represented the histopathologic features used for diagnosing squamous dysplasia. The study suggests that sLSM technology has the potential to enhance the efficacy of anal cancer screening by providing accurate sampling of diagnostic tissue during anoscopy. The researchers are currently developing a handheld device for in vivo imaging. [Extracted from the article]

A new study conducted by researchers at the National Cancer Institute (NCI) compared the effectiveness of primary human papillomavirus (HPV) testing versus concurrent HPV and cytology testing (cotesting) in different populations. The study found that cotesting required more lab tests and colposcopies compared to primary HPV testing. Additionally, the detection of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) through cotesting decreased as the population-average CIN3+ prevalence decreased. These findings suggest that primary HPV testing may be more beneficial than cotesting. For more information, the full research article can be accessed for free at the provided link. [Extracted from the article]

A recent study conducted by the Italian Institute of Technology in Pisa, Italy, explores a potential alternative to the standard treatment for locally advanced human papillomavirus-positive head/neck carcinoma. The study suggests that nonpersistent gold nanoarchitectures containing cisplatin, when combined with radiotherapy, have a significant tumor-reducing effect and can achieve complete tumor clearance in some cases. These findings indicate that this approach may enhance treatment outcomes and improve the quality of life for patients. Further research is needed, but this study supports the use of nonpersistent metal-nanomaterial-mediated approaches for oral cancer management. [Extracted from the article]

A recent study from the University of Massachusetts Chan Medical School explores the molecular mechanisms of human papillomavirus (HPV) related skin cancers. While HPV is known to play a role in various types of cancer, such as oral cavity, cervix, vagina, anus, and vulva, its involvement in skin malignancies is not fully understood. The study focuses on the role of HPV in cutaneous squamous cell carcinoma (cSCC), basal cell carcinoma (BCC), and melanoma, providing an overview of the epidemiological, pathophysiological, and molecular aspects of HPV's involvement in skin cancers. This research contributes to a better understanding of the relationship between HPV and skin cancer. [Extracted from the article]