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14 results on '"Finetti, Pascal"'

1. PVRIG Expression Is an Independent Prognostic Factor and a New Potential Target for Immunotherapy in Hepatocellular Carcinoma

Author

Birnbaum, David Jeremie, primary, Picard, Maelle, additional, Da Costa, Quentin, additional, Delayre, Thomas, additional, Finetti, Pascal, additional, Cabaud, Olivier, additional, Agavnian, Emilie, additional, De Rauglaudre, Bernadette, additional, Denicolaï, Emilie, additional, Bertucci, François, additional, and Mamessier, Emilie, additional

Published
2023
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3. Molecular Profiles of Advanced Urological Cancers in the PERMED-01 Precision Medicine Clinical Trial

Author

Billon, Emilien, primary, Gravis, Gwenaelle, additional, Guille, Arnaud, additional, Carbuccia, Nadine, additional, Adelaide, Jose, additional, Garnier, Séverine, additional, Finetti, Pascal, additional, Denicolaï, Emilie, additional, Sfumato, Patrick, additional, Brunelle, Serge, additional, Thomassin-Piana, Jeanne, additional, Pignot, Géraldine, additional, Walz, Jochen, additional, Chabannon, Christian, additional, Pakradouni, Jihane, additional, Sabatier, Renaud, additional, Vicier, Cécile, additional, Popovici, Cornel, additional, Mamessier, Emilie, additional, Gonçalves, Anthony, additional, Birnbaum, Daniel, additional, Chaffanet, Max, additional, and Bertucci, François, additional

Published
2022
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5. Identification of Atypical Circulating Tumor Cells with Prognostic Value in Metastatic Breast Cancer Patients

Author

Lopresti, Alexia, primary, Acquaviva, Claire, additional, Boudin, Laurys, additional, Finetti, Pascal, additional, Garnier, Séverine, additional, Aulas, Anaïs, additional, Liberatoscioli, Maria Lucia, additional, Cabaud, Olivier, additional, Guille, Arnaud, additional, de Nonneville, Alexandre, additional, Da Costa, Quentin, additional, Denicolai, Emilie, additional, Pakradouni, Jihane, additional, Goncalves, Anthony, additional, Birnbaum, Daniel, additional, Bertucci, François, additional, and Mamessier, Emilie, additional

Published
2022
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6. Expression of X-Linked Inhibitor of Apoptosis Protein (XIAP) in Breast Cancer Is Associated with Shorter Survival and Resistance to Chemotherapy

Author

Devi, Gayathri R., primary, Finetti, Pascal, additional, Morse, Michael A., additional, Lee, Seayoung, additional, de Nonneville, Alexandre, additional, Van Laere, Steven, additional, Troy, Jesse, additional, Geradts, Joseph, additional, McCall, Shannon, additional, and Bertucci, Francois, additional

Published
2021
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7. Enhancement of Breast Cancer Cell Aggressiveness by lncRNA H19 and its Mir-675 Derivative: Insight into Shared and Different Actions

Author

Peperstraete, Evodie, Lecerf, Clément, Collette, Jordan, Vennin, Constance, Raby, Ludivine, Völkel, Pamela, Angrand, Pierre-Olivier, Winter, Marie, Bertucci, Francois, Finetti, Pascal, Lagadec, Chann, Meignan, Samuel, Bourette, Roland, Bourhis, Xuefen Le, Adriaenssens, Eric, Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Signalisation des Facteurs de Croissance Dans Le Cancer du Sein . Proteomique Fonctionnelle, Université de Lille, Sciences et Technologies-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Signalisation des facteurs de croissance dans le cancer du sein. Protéomique fonctionnelle, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, CHU Lille, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)

Subjects
H19 gene, cancer stem cell, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, miR-675, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, female genital diseases and pregnancy complications, Article, LncRNA, breast cancer, tumoral progression, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], embryonic structures, ComputingMilieux_MISCELLANEOUS
Abstract

Breast cancer is a major public health problem and the leading world cause of women death by cancer. Both the recurrence and mortality of breast cancer are mainly caused by the formation of metastasis. The long non-coding RNA H19, the precursor of miR-675, is involved in breast cancer development. The aim of this work was to determine the implication but, also, the relative contribution of H19 and miR-675 to the enhancement of breast cancer metastatic potential. We showed that both H19 and miR-675 increase the invasive capacities of breast cancer cells in xenografted transgenic zebrafish models. In vitro, H19 and miR-675 enhance the cell migration and invasion, as well as colony formation. H19 seems to induce the epithelial-to-mesenchymal transition (EMT), with a decreased expression of epithelial markers and an increased expression of mesenchymal markers. Interestingly, miR-675 simultaneously increases the expression of both epithelial and mesenchymal markers, suggesting the induction of a hybrid phenotype or mesenchymal-to-epithelial transition (MET). Finally, we demonstrated for the first time that miR-675, like its precursor H19, increases the stemness properties of breast cancer cells. Altogether, our data suggest that H19 and miR-675 could enhance the aggressiveness of breast cancer cells through both common and different mechanisms.

Published
2020

8. Novel Therapeutic Insights in Dedifferentiated Liposarcoma: A Role for FGFR and MDM2 Dual Targeting

Author

Dadone-Montaudié, Bérengère, primary, Laroche-Clary, Audrey, additional, Mongis, Aline, additional, Chamorey, Emmanuel, additional, Di Mauro, Ilaria, additional, Chaire, Vanessa, additional, Finetti, Pascal, additional, Schiappa, Renaud, additional, Le Loarer, François, additional, Birtwisle-Peyrottes, Isabelle, additional, Michiels, Jean-François, additional, Bertucci, François, additional, Pedeutour, Florence, additional, Italiano, Antoine, additional, and Bianchini, Laurence, additional

Published
2020
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10. Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

Author

Doghman-Bouguerra, Mabrouka, primary, Finetti, Pascal, additional, Durand, Nelly, additional, Parise, Ivy Zortéa S., additional, Sbiera, Silviu, additional, Cantini, Giulia, additional, Canu, Letizia, additional, Hescot, Ségolène, additional, Figueiredo, Mirna M. O., additional, Komechen, Heloisa, additional, Sbiera, Iuliu, additional, Nesi, Gabriella, additional, Paci, Angelo, additional, Al Ghuzlan, Abir, additional, Birnbaum, Daniel, additional, Baudin, Eric, additional, Luconi, Michaela, additional, Fassnacht, Martin, additional, Figueiredo, Bonald C., additional, Bertucci, François, additional, and Lalli, Enzo, additional

Published
2020
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11. Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors

Author

Aoki, Shuichi, Inoue, Koetsu, Klein, Sebastian, Halvorsen, Stefan, Chen, Jiang, Matsui, Aya, Nikmaneshi, Mohammad, Kitahara, Shuji, Hato, Tai, Chen, Xianfeng, Kawakubo, Kazumichi, Nia, Hadi, Chen, Ivy, Schanne, Daniel, Shigeta, Kohei, Kikuchi, Hiroto, Ramjiawan, Rakesh, Schmidt, Tyge Ce, Iwasaki, Masaaki, Yau, Thomas, Hong, Theodore, Quaas, Alexander, Plum, Patrick, Dima, Simona, Popescu, Irinel, Bardeesy, Nabeel, Munn, Lance, Borad, Mitesh, Sassi, Slim, Jain, Rakesh, Zhu, Andrew, Duda, Dan, Guo, Yuchen, Gabola, Monica, Lattanzio, Rossano, Paul, Conception, Pinet, Valérie, Tang, Ruizhi, Turali, Hulya, Bremond, Julie, Longobardi, Ciro, Maurizy, Chloé, da Costa, Quentin, Finetti, Pascal, Boissière-Michot, Florence, Rivière, Benjamin, Lemmers, Céline, Garnier, Séverine, Bertucci, François, Zlobec, Inti, Chebli, Karim, Tazi, Jamal, Azar, Rania, Blanchard, Jean-Marie, Sicinski, Peter, Lemmers, Bénédicte, Hahne, Michael, Gonçalves, Anthony, Guille, Arnaud, Adelaïde, José, Carbuccia, Nadine, Billon, Emilien, Sfumato, Patrick, Monneur, Audrey, Pécheux, Christophe, Khran, Martin, Brunelle, Serge, Mescam, Lenaïg, Thomassin-Piana, Jeanne, Poizat, Flora, Charafe-Jauffret, Emmanuelle, Turrini, Olivier, Lambaudie, Eric, Provansal, Magali, Extra, Jean-Marc, Madroszyk, Anne, Gilabert, Marine, Sabatier, Renaud, Vicier, Cécile, Chabannon, Christian, Pakradouni, Jihane, Viens, Patrice, André, Fabrice, Gravis, Gwenaelle, Popovici, Cornel, Birnbaum, Daniel, Chaffanet, Max, Amoozgar, Zohreh, Kloepper, Jonas, Ren, Jun, Tay, Rong En, Kazer, Samuel, Kiner, Evgeny, Krishnan, Shanmugarajan, Posada, Jessica, Ghosh, Mitrajit, Wong, Christina, Ferraro, Gino, Batista, Ana, Wang, Nancy, Badeaux, Mark, Roberge, Sylvie, Xu, Lei, Huang, Peigen, Shalek, Alex, Fukumura, Dai, Kim, Hye-Jung, Shigeta, Ayako, Staiculescu, Daniel, Zopf, Dieter, Fiebig, Lukas, Hobbs, Gabriela, Cobbold, Mark, Goyal, Lipika, Birnbaum, David, Mamessier, Emilie, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Cancer Research, Pancreatic ductal adenocarcinoma, endocrine system diseases, pancreatic cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, lcsh:RC254-282, survival, Article, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Pancreatic cancer, Gene expression, medicine, Gene, tumor location, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Phenotype, digestive system diseases, Gene expression profiling, medicine.anatomical_structure, Oncology, expression profiling, 030220 oncology & carcinogenesis, Cancer research, 030211 gastroenterology & hepatology, prognosis, Pancreas
Abstract

The association between pancreatic ductal adenocarcinoma (PDAC) location (head vs. Body/Tail (B/T)) and clinical outcome remains controversial. We collected clinicopathological and gene expression data from 249 resected PDAC samples from public data sets, and we compared data between 208 head and 41 B/T samples. The 2-year overall survival (OS) was better for the head than for the B/T PDACs (44 vs. 27%, p = 0.043), especially when comparing tumors with similar TNM classification (T3/4N0M0: 67% vs. 17%, p = 0.002) or from the same molecular class (squamous subtype: 31% vs. 0%, p &lt, 0.0001). Bailey&rsquo, s molecular subtypes were differentially distributed within the two groups, with the immunogenic subtype being underrepresented in the &ldquo, B/T&rdquo, group (p = 0.005). Uni- and multivariate analyses indicated that PDAC anatomic location was an independent prognostic factor. Finally, the supervised analysis identified 334 genes differentially expressed. Genes upregulated in the &ldquo, head&rdquo, group suggested lymphocyte activation and pancreas exocrine functions. Genes upregulated in the &ldquo, group were related to keratinocyte differentiation, in line with the enrichment for squamous phenotype. We identified a robust gene expression signature (GES) associated with B/T PDAC location, suggesting that head and B/T PDAC are different. This GES could serve as an indicator for differential therapeutic management based on PDAC location.

Published
2019

13. A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases

Author

Tyran, Marguerite, primary, Carbuccia, Nadine, additional, Garnier, Séverine, additional, Guille, Arnaud, additional, Adelaïde, José, additional, Finetti, Pascal, additional, Touzlian, Julien, additional, Viens, Patrice, additional, Tallet, Agnès, additional, Goncalves, Anthony, additional, Metellus, Philippe, additional, Birnbaum, Daniel, additional, Chaffanet, Max, additional, and Bertucci, François, additional

Published
2019
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