Search

Your search keyword '"Jöhrens, Korinna"' showing total 5 results
Start Over Author "Jöhrens, Korinna" Journal cancers
5 results on '"Jöhrens, Korinna"'

1. The Immune Contexture of Liposarcoma and Its Clinical Implications

Author

Resag, Antonia, primary, Toffanin, Giulia, additional, Benešová, Iva, additional, Müller, Luise, additional, Potkrajcic, Vlatko, additional, Ozaniak, Andrej, additional, Lischke, Robert, additional, Bartunkova, Jirina, additional, Rosato, Antonio, additional, Jöhrens, Korinna, additional, Eckert, Franziska, additional, Strizova, Zuzana, additional, and Schmitz, Marc, additional

Published
2022
Full Text
View/download PDF

3. Aberrant Expression of and Cell Death Induction by Engagement of the MHC-II Chaperone CD74 in Anaplastic Large Cell Lymphoma (ALCL)

Author

Wurster, Kathrin, primary, Costanza, Mariantonia, additional, Kreher, Stephan, additional, Glaser, Selina, additional, Lamprecht, Björn, additional, Schleussner, Nikolai, additional, Anagnostopoulos, Ioannis, additional, Hummel, Michael, additional, Jöhrens, Korinna, additional, Stein, Harald, additional, Molina, Arturo, additional, Diepstra, Arjan, additional, Gillissen, Bernd, additional, Köchert, Karl, additional, Siebert, Reiner, additional, Merkel, Olaf, additional, Kenner, Lukas, additional, Janz, Martin, additional, and Mathas, Stephan, additional

Published
2021
Full Text
View/download PDF

4. Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive Microenvironment

Author

Busse, Antonia, primary, Mochmann, Liliana H., additional, Spenke, Christiane, additional, Arsenic, Ruza, additional, Briest, Franziska, additional, Jöhrens, Korinna, additional, Lammert, Hedwig, additional, Sipos, Bence, additional, Kühl, Anja A., additional, Wirtz, Ralph, additional, Pavel, Marianne, additional, Hummel, Michael, additional, Kaemmerer, Daniel, additional, Baum, Richard P., additional, and Grabowski, Patricia, additional

Published
2020
Full Text
View/download PDF

5. A Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT.

Author

Patil S, Linge A, Hiepe H, Grosser M, Lohaus F, Gudziol V, Kemper M, Nowak A, Haim D, Tinhofer I, Budach V, Guberina M, Stuschke M, Balermpas P, Grün JV, Schäfer H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Boeke S, Zips D, Jöhrens K, Baretton GB, Baumann M, Krause M, Löck S, and On Behalf Of The Dktk-Rog

Abstract

(1) Background: Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who are biologically at high risk for the development of loco−regional recurrences after postoperative radiotherapy (PORT) but at intermediate risk according to clinical risk factors may benefit from additional concurrent chemotherapy. In this matched-pair study, we aimed to identify a corresponding predictive gene signature. (2) Methods: Gene expression analysis was performed on a multicenter retrospective cohort of 221 patients that were treated with postoperative radiochemotherapy (PORT-C) and 283 patients who were treated with PORT alone. Propensity score analysis was used to identify matched patient pairs from both cohorts. From differential gene expression analysis and Cox regression, a predictive gene signature was identified. (3) Results: 108 matched patient pairs were selected. We identified a 2-metagene signature that stratified patients into risk groups in both cohorts. The comparison of the high-risk patients between the two types of treatment showed higher loco−regional control (LRC) after treatment with PORT-C (p < 0.001), which was confirmed by a significant interaction term in Cox regression (p = 0.027), i.e., the 2-metagene signature was indicative for the type of treatment. (4) Conclusion: We have identified a novel gene signature that may be helpful to identify patients with high-risk HNSCC amongst those at intermediate clinical risk treated with PORT, who may benefit from additional concurrent chemotherapy.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results