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Your search keyword '"Koutras, Angelos"' showing total 9 results
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9 results on '"Koutras, Angelos"'

2. Small Extracellular Vesicles (sEVs) Biogenesis Molecular Players Are Associated with Clinical Outcome of Colorectal Cancer Patients

Author

Kottorou, Anastasia, primary, Dimitrakopoulos, Foteinos-Ioannis, additional, Diamantopoulou, Georgia, additional, Kalofonou, Foteini, additional, Stavropoulos, Michalis, additional, Thomopoulos, Konstantinos, additional, Makatsoris, Thomas, additional, Koutras, Angelos, additional, and Kalofonos, Haralabos, additional

Published
2023
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3. Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients

Author

Roumeliotou, Argyro, primary, Pantazaka, Evangelia, additional, Xagara, Anastasia, additional, Dimitrakopoulos, Foteinos-Ioannis, additional, Koutras, Angelos, additional, Christopoulou, Athina, additional, Kourelis, Theodoros, additional, Aljarba, Nada H., additional, Alkahtani, Saad, additional, Koinis, Filippos, additional, Kotsakis, Athanasios, additional, and Kallergi, Galatea, additional

Published
2022
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4. Association between CD8+ Tumor Infiltrating Lymphocytes and the Clinical Outcome of Patients with Operable Breast Cancer Treated with Adjuvant Dose-Dense Chemotherapy—A 10 Year Follow-Up Report of a Hellenic Cooperative Oncology Group Observational Study

Author

Spathas, Nikolaos, primary, Goussia, Anna C., additional, Koliou, Georgia-Angeliki, additional, Gogas, Helen, additional, Zagouri, Flora, additional, Batistatou, Anna, additional, Charchanti, Antonia V., additional, Papoudou-Bai, Alexandra, additional, Bobos, Mattheos, additional, Chrisafi, Sofia, additional, Chatzopoulos, Kyriakos, additional, Kostopoulos, Ioannis, additional, Koletsa, Triantafyllia, additional, Arapantoni, Petroula, additional, Pectasides, Dimitrios, additional, Galani, Eleni, additional, Koutras, Angelos, additional, Zarkavelis, George, additional, Saloustros, Emmanouil, additional, Bafaloukos, Dimitrios, additional, Karanikiotis, Charisios, additional, Bompolaki, Iliada, additional, Aravantinos, Gerasimos, additional, Psyrri, Amanda, additional, Razis, Evangelia, additional, Koumarianou, Anna, additional, Res, Eleni, additional, Linardou, Helena, additional, and Fountzilas, George, additional

Published
2022
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6. Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients.

Author

Roumeliotou, Argyro, Pantazaka, Evangelia, Xagara, Anastasia, Dimitrakopoulos, Foteinos-Ioannis, Koutras, Angelos, Christopoulou, Athina, Kourelis, Theodoros, Aljarba, Nada H., Alkahtani, Saad, Koinis, Filippos, Kotsakis, Athanasios, and Kallergi, Galatea

Subjects
LUNG cancer prognosis, SMALL cell carcinoma, MICROSCOPY, METASTASIS, CANCER patients, GENE expression, TUMOR classification, RESEARCH funding, TUMOR markers, TRANSCRIPTION factors, PROGRESSION-free survival, PHENOTYPES, OVERALL survival, PROPORTIONAL hazards models
Abstract

Simple Summary: Studies have shown that JUNB and CXCR4 contribute to cell proliferation, migration and invasion, hence claiming an important role in tumor progression and metastasis, in various cancer types, including lung cancer. We have previously reported that JUNB and CXCR4 are overexpressed in circulating and disseminated tumor cells from breast cancer patients and are correlated with worse survival. In the present study, we investigated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of non-small-cell lung cancer and small-cell lung cancer patients and determined their clinical significance. Our results showed that both JUNB and CXCR4 were overexpressed in CTCs from lung cancer patients. Furthermore, both proteins were correlated with poor survival in non-small-cell lung cancer patients, while only CXCR4 was associated with worse survival in small-cell lung cancer patients, suggesting that JUNB and CXCR4 are potentially important prognostic biomarkers for lung cancer. In the present study, we evaluated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients and investigated whether these proteins have prognostic clinical relevance. Peripheral blood from 30 patients with non-small-cell lung cancer (NSCLC) was filtered using ISET membranes, and cytospins from 37 patients with small-cell lung cancer (SCLC) were analyzed using confocal and VyCAP microscopy. Both JUNB and CXCR4 were expressed in the vast majority of lung cancer patients. Interestingly, the phenotypic patterns differed between NSCLC and SCLC patients; the (CK+/JUNB+/CXCR4+) phenotype was present in 50% of NSCLC vs. 71% of SCLC patients. Similarly, the (CK+/JUNB+/CXCR4–) was present in 44% vs. 71%, the (CK+/JUNB–/CXCR4+) in 6% vs. 71%, and the (CK+/JUNB–/CXCR4–) phenotype in 38% vs. 84%. In NSCLC, the presence of ≥1 CTCs with the (CK+/JUNB+/CXCR4+) phenotype was associated with worse progression-free survival (PFS) (p = 0.007, HR = 5.21) while ≥2 with poorer overall survival (OS) (p < 0.001, HR = 2.16). In extensive stage SCLC patients, the presence of ≥4 CXCR4-positive CTCs was associated with shorter OS (p = 0.041, HR = 5.01). Consequently, JUNB and CXCR4 were expressed in CTCs from lung cancer patients, and associated with patients' survival, underlying their key role in tumor progression. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Genetic Variation in the Vascular Endothelial Growth Factor (VEGFA) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer

Author

Dimitrakopoulos, Foteinos-Ioannis, primary, Koliou, Georgia-Angeliki, additional, Kotoula, Vassiliki, additional, Papadopoulou, Kyriaki, additional, Markou, Konstantinos, additional, Vlachtsis, Konstantinos, additional, Angouridakis, Nikolaos, additional, Karasmanis, Ilias, additional, Nikolaou, Angelos, additional, Psyrri, Amanda, additional, Visvikis, Anastasios, additional, Kosmidis, Paris, additional, Fountzilas, George, additional, and Koutras, Angelos, additional

Published
2021
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8. PIOS (Patras Immunotherapy Score) Score Is Associated with Best Overall Response, Progression-Free Survival, and Post-Immunotherapy Overall Survival in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) Treated with Anti-Program Cell Death-1 (PD-1) Inhibitors

Author

Dimitrakopoulos, Foteinos-Ioannis, primary, Nikolakopoulos, Achilleas, additional, Kottorou, Anastasia, additional, Kalofonou, Fotini, additional, Liolis, Elias, additional, Frantzi, Theodora, additional, Pyrousis, Ioannis, additional, Koutras, Angelos, additional, Makatsoris, Thomas, additional, and Kalofonos, Haralabos, additional

Published
2020
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9. Differentially Methylated Ultra-Conserved Regions Uc160 and Uc283 in Adenomas and Adenocarcinomas Are Associated with Overall Survival of Colorectal Cancer Patients

Author

Kottorou, Anastasia E., primary, Dimitrakopoulos, Foteinos-Ioannis D., additional, Antonacopoulou, Anna G., additional, Diamantopoulou, Georgia, additional, Tsoumas, Dimitrios, additional, Koutras, Angelos, additional, Makatsoris, Thomas, additional, Stavropoulos, Michalis, additional, Thomopoulos, Konstantinos C., additional, Hulbert, Alicia, additional, Tzelepi, Vassiliki, additional, and Kalofonos, Haralabos P., additional

Published
2020
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