1. Intercellular Communication in the Brain through Tunneling Nanotubes
- Author
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Khattar E. Khattar, Janice Safi, Anne-Marie Rodriguez, Marie-Luce Vignais, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation ARC pour la Recherche sur le Cancer, INCa-Cancéropôle GSO, Fondation de l’Avenir (AP-RM-19-001), Ligue Contre le Cancer, Région Occitanie-GliMit and SATT-AxLR, ANR-20-CE18-0035,MiMeTiC,Les mitochondries pour stimuler les capacités thérapeutiques des cellules souches mésenchymateuses pour l'ischémie cardiaque(2020), Vignais, Marie-Luce, and Les mitochondries pour stimuler les capacités thérapeutiques des cellules souches mésenchymateuses pour l'ischémie cardiaque - - MiMeTiC2020 - ANR-20-CE18-0035 - AAPG2020 - VALID
- Subjects
Cancer Research ,mesenchymal stem cells (MSCs) ,brain ,[SDV]Life Sciences [q-bio] ,astrocytes ,neurons ,degenerative brain diseases ,mitochondria ,[SDV] Life Sciences [q-bio] ,tunneling nanotubes ,Oncology ,glioma ,tumor microenvironment ,glioblastoma stem cells (GSCs) - Abstract
International audience; Intercellular communication is essential for tissue homeostasis and function. Understanding how cells interact with each other is paramount, as crosstalk between cells is often dysregulated in diseases and can contribute to their progression. Cells communicate with each other through several modalities, including paracrine secretion and specialized structures ensuring physical contact between them. Among these intercellular specialized structures, tunneling nanotubes (TNTs) are now recognized as a means of cell-to-cell communication through the exchange of cellular cargo, controlled by a variety of biological triggers, as described here. Intercellular communication is fundamental to brain function. It allows the dialogue between the many cells, including neurons, astrocytes, oligodendrocytes, glial cells, microglia, necessary for the proper development and function of the brain. We highlight here the role of TNTs in connecting these cells, for the physiological functioning of the brain and in pathologies such as stroke, neurodegenerative diseases, and gliomas. Understanding these processes could pave the way for future therapies.
- Published
- 2022