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8 results on '"Stilgenbauer, Stephan"'

1. Venetoclax Initiation in Chronic Lymphocytic Leukemia: International Insights and Innovative Approaches for Optimal Patient Care

Author

Anderson, Mary Ann, primary, Walewska, Renata, additional, Hackett, Fidelma, additional, Kater, Arnon P., additional, Montegaard, Josie, additional, O’Brien, Susan, additional, Seymour, John F., additional, Smith, Matthew, additional, Stilgenbauer, Stephan, additional, Whitechurch, Ashley, additional, and Brown, Jennifer R., additional

Published
2024
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3. Deep Neural Networks and Machine Learning Radiomics Modelling for Prediction of Relapse in Mantle Cell Lymphoma

Author

Lisson, Catharina Silvia, primary, Lisson, Christoph Gerhard, additional, Mezger, Marc Fabian, additional, Wolf, Daniel, additional, Schmidt, Stefan Andreas, additional, Thaiss, Wolfgang M., additional, Tausch, Eugen, additional, Beer, Ambros J., additional, Stilgenbauer, Stephan, additional, Beer, Meinrad, additional, and Goetz, Michael, additional

Published
2022
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4. To β or Not to β: How Important Is β-Catenin Dependent and Independent WNT Signaling in CLL?

Author

Urbanek, Karol D., Stilgenbauer, Stephan, and Mertens, Daniel

Subjects
*THERAPEUTIC use of antineoplastic agents, *CHRONIC lymphocytic leukemia, *GENETIC mutation, *CYTOSKELETAL proteins, *WNT proteins, *CELL receptors, *CELLULAR signal transduction, *CELL lines, *CHEMICAL inhibitors
Abstract

Simple Summary: This review aims to present the current state of WNT signaling in chronic lymphocytic leukemia. First, we briefly summarize WNT pathways in physiological conditions and cancer. Then, we focus on WNT pathways in CLL with an emphasis on ROR1. The problem of limited data on canonical WNT signaling in CLL is also highlighted. In conclusion, we suggest that further research should focus on understanding the role of β-catenin signaling in CLL. WNT pathways play an important role in cancer development and progression, but WNT pathways can also inhibit growth in melanoma, prostate, and ovarian cancers. Chronic lymphocytic leukemia (CLL) is known for its overexpression of several WNT ligands and receptors. Canonical WNT signaling is β-catenin-dependent, whereas non-canonical WNT signaling is β-catenin-independent. Research on WNT in CLL focuses mainly on non-canonical signaling due to the high expression of the WNT-5a receptor ROR1. However, it was also shown that mutations in canonical WNT pathway genes can lead to WNT activation in CLL. The focus of this review is β-catenin-independent signaling and β-catenin-dependent signaling within CLL cells and the role of WNT in the leukemic microenvironment. The major role of WNT pathways in CLL pathogenesis also makes WNT a possible therapeutic target, directly or in combination with other drugs. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Longitudinal CT Imaging to Explore the Predictive Power of 3D Radiomic Tumour Heterogeneity in Precise Imaging of Mantle Cell Lymphoma (MCL)

Author

Lisson, Catharina Silvia, primary, Lisson, Christoph Gerhard, additional, Achilles, Sherin, additional, Mezger, Marc Fabian, additional, Wolf, Daniel, additional, Schmidt, Stefan Andreas, additional, Thaiss, Wolfgang M., additional, Bloehdorn, Johannes, additional, Beer, Ambros J., additional, Stilgenbauer, Stephan, additional, Beer, Meinrad, additional, and Götz, Michael, additional

Published
2022
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6. Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas

Author

Hartmann, Sylvia, primary, Scharf, Sonja, additional, Steiner, Yvonne, additional, Loth, Andreas G., additional, Donnadieu, Emmanuel, additional, Flinner, Nadine, additional, Poeschel, Viola, additional, Angel, Stephanie, additional, Bewarder, Moritz, additional, Bein, Julia, additional, Brunnberg, Uta, additional, Bozzato, Alessandro, additional, Schick, Bernhard, additional, Stilgenbauer, Stephan, additional, Bohle, Rainer M., additional, Thurner, Lorenz, additional, and Hansmann, Martin-Leo, additional

Published
2021
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8. Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia

Author

Schulze-Edinghausen, Lena, primary, Dürr, Claudia, additional, Öztürk, Selcen, additional, Zucknick, Manuela, additional, Benner, Axel, additional, Kalter, Verena, additional, Ohl, Sibylle, additional, Close, Viola, additional, Wuchter, Patrick, additional, Stilgenbauer, Stephan, additional, Lichter, Peter, additional, and Seiffert, Martina, additional

Published
2019
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