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8 results on '"Willems, Stefan M."'

3. Targeting Angiogenesis in Squamous Cell Carcinoma of the Head and Neck: Opportunities in the Immunotherapy Era

Author

Saba, Nabil F., primary, Vijayvargiya, Pooja, additional, Vermorken, Jan B., additional, Rodrigo, Juan P., additional, Willems, Stefan M., additional, Zidar, Nina, additional, de Bree, Remco, additional, Mäkitie, Antti, additional, Wolf, Greg T., additional, Argiris, Athanassios, additional, Teng, Yong, additional, and Ferlito, Alfio, additional

Published
2022
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4. The Hidden Link of Exosomes to Head and Neck Cancer

Author

Teng, Yong, primary, Gao, Lixia, additional, Loveless, Reid, additional, Rodrigo, Juan P., additional, Strojan, Primož, additional, Willems, Stefan M., additional, Nathan, Cherie-Ann, additional, Mäkitie, Antti A., additional, Saba, Nabil F., additional, and Ferlito, Alfio, additional

Published
2021
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5. SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target

Author

Emanuel, Oscar, primary, Liu, Jacklyn, additional, Schartinger, Volker H., additional, Nei, Wen Long, additional, Chan, Yuk Yu, additional, Tsang, Chi Man, additional, Riechelmann, Herbert, additional, Masterson, Liam, additional, Haybaeck, Johannes, additional, Oppermann, Udo, additional, Willems, Stefan M., additional, Ooft, Marc L., additional, Wollmann, Guido, additional, Howard, David, additional, Vanhaesebroeck, Bart, additional, Lund, Valerie J., additional, Royle, Gary, additional, Chua, Melvin L. K., additional, Lo, Kwok Wai, additional, Busson, Pierre, additional, and Lechner, Matt, additional

Published
2021
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6. A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses

Author

Koopman, Bart, primary, Cajiao Garcia, Betzabel N., additional, Kuijpers, Chantal C. H. J., additional, Damhuis, Ronald A. M., additional, van der Wekken, Anthonie J., additional, Groen, Harry J. M., additional, Schuuring, Ed, additional, Willems, Stefan M., additional, and van Kempen, Léon C., additional

Published
2021
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7. Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience

Author

den Toom, Inne J., primary, Boeve, Koos, additional, Lobeek, Daphne, additional, Bloemena, Elisabeth, additional, Donswijk, Maarten L., additional, de Keizer, Bart, additional, Klop, W. Martin C., additional, Leemans, C. René, additional, Willems, Stefan M., additional, Takes, Robert P., additional, Witjes, Max J.H., additional, and de Bree, Remco, additional

Published
2020
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8. Feasibility of Primary Tumor Culture Models and Preclinical Prediction Assays for Head and Neck Cancer: A Narrative Review.

Author

Dohmen, Amy J. C., Swartz, Justin E., Van Den Brekel, MichielW M., Willems, Stefan M., Spijker, René, Neefjes, Jacques, and Zuur, Charlotte L.

Abstract

Primary human tumor culture models allow for individualized drug sensitivity testing and are therefore a promising technique to achieve personalized treatment for cancer patients. This would especially be of interest for patients with advanced stage head and neck cancer. They are extensively treated with surgery, usually in combination with high-dose cisplatin chemoradiation. However, adding cisplatin to radiotherapy is associated with an increase in severe acute toxicity, while conferring only a minor overall survival benefit. Hence, there is a strong need for a preclinical model to identify patients that will respond to the intended treatment regimen and to test novel drugs. One of such models is the technique of culturing primary human tumor tissue. This review discusses the feasibility and success rate of existing primary head and neck tumor culturing techniques and their corresponding chemo- and radiosensitivity assays. A comprehensive literature search was performed and success factors for culturing in vitro are debated, together with the actual value of these models as preclinical prediction assay for individual patients. With this review, we aim to fill a gap in the understanding of primary culture models from head and neck tumors, with potential importance for other tumor types as well. [ABSTRACT FROM AUTHOR]

Published
2015
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