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Citronellol (CI)-loaded, chitosan (CS)-enclosed dendritic mesoporous organosilica nanoparticles (CI@D-MONs@CS) are successfully fabricated. The synthesized CI@D-MONs@CS present spherical shape with the particle size of 424±24 nm in diameter and dendritic mesopores. CI loading ratio of CI@D-MONs@CS is about 12.42% from TGA analysis. CI release from CI@D-MONs@CS exhibits pH-redox dual responsiveness. More interesting, the axillary deodorant effect is investigated with Staphylococcus haemolyticus in an artificial sweat model. The results show that CI@D-MONs@CS present an excellent bacteria-killing effect and the smell of artificial sweat is greatly improved, avoiding the formation of undesirable odorant compounds from the bacteria. The obtained CI@D-MONs@CS is a potential carrier of natural fragrance or actives with dual responsive release. The application of CI@D-MONs@CS is a new and effective strategy to the axillary odor problem. • The pH-redox dual responsive nanoparticles CI@D-MONs@CS were designed and fabricated. • Chitosan formed the pH-responsive "gate" of CI@D-MONs@CS. • CI@D-MONs@CS exhibited significantly enhanced and durable antibacterial capacities. • CI@D-MONs@CS greatly reduced the off-odor caused by the axillary bacteria. • Application of CI@D-MONs@CS was a new and effective strategy to the axillary odor problem. [ABSTRACT FROM AUTHOR]