1. Polydopamine-coated curdlan hydrogel as a potential carrier of free amino group-containing molecules.
- Author
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Michalicha A, Pałka K, Roguska A, Pisarek M, and Belcarz A
- Subjects
- Anti-Bacterial Agents pharmacology, Bacterial Adhesion drug effects, Coated Materials, Biocompatible pharmacology, Drug Carriers, Drug Compounding methods, Drug Liberation, Elasticity, Escherichia coli drug effects, Escherichia coli growth & development, Gentamicins pharmacology, Humans, Hydrogels pharmacology, Kinetics, Microbial Sensitivity Tests, Solubility, Staphylococcus aureus drug effects, Staphylococcus aureus growth & development, Staphylococcus epidermidis drug effects, Staphylococcus epidermidis growth & development, Wettability, Anti-Bacterial Agents metabolism, Coated Materials, Biocompatible chemical synthesis, Gentamicins metabolism, Hydrogels chemical synthesis, Indoles chemistry, Polymers chemistry, beta-Glucans chemistry
- Abstract
Curdlan hydrogel obtained after thermal gelling exhibits elasticity and high water-absorbing capacity. However, its modifications leading to the increase of biofunctionality usually alter its solubility and reduce mechanical parameters. Therefore, curdlan hydrogel was modified by deposition of polydopamine to improve its capacity to bind biologically active molecules with free amino groups. It exhibited the unchanged structure, mechanical properties and increased soaking capacity. Aminoglycoside antibiotic (gentamicin) as a model molecule was effectively immobilized to such modified curdlan via quinone moiety (but not amino groups) of polydopamine. Approximately 50 % of the immobilized drug was released following Fickian diffusion and inhibited the bacterial growth in matrix-surrounding medium in prolonged manner. The remaining drug amount was stably attached and prevented the hydrogel against bacterial adhesion even when all the mobile drug has been released. Therefore, polydopamine-modified curdlan hydrogel shows the potential for fabrication of functional materials for different purposes, including drug-loaded biomaterials., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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