1. Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy
- Author
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Lillian Maria Uchoa Dutra Fechine, Rafael M. Freire, Adolfo I. B. Romo, Aiêrta Cristina Carrá da Silva, Otília Deusdênia L. Pessoa, Daniel Pascoalino Pinheiro, Alexandre C.C. Sousa, Larissa Morais Ribeiro da Silva, Claudia Pessoa, Nágila M.P.S. Ricardo, Raimundo Rafael de Almeida, Débora Hellen Almeida de Brito, and Juliano C. Denardin
- Subjects
Male ,Nanostructure ,Polymers and Plastics ,Starch ,Anthraquinones ,02 engineering and technology ,Hydroxyethyl starch ,010402 general chemistry ,01 natural sciences ,Nanocapsules ,Nanocomposites ,chemistry.chemical_compound ,Drug Delivery Systems ,Cell Line, Tumor ,Neoplasms ,Materials Chemistry ,medicine ,Animals ,Humans ,IC50 ,Zebrafish ,Drug Carriers ,Nanocomposite ,Chemistry ,Organic Chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,0104 chemical sciences ,Drug Liberation ,Magnetic Fields ,Cell culture ,Biophysics ,Magnetic Iron Oxide Nanoparticles ,0210 nano-technology ,Glioblastoma ,Hydrophobic and Hydrophilic Interactions ,medicine.drug - Abstract
Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.
- Published
- 2021