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Your search keyword '"Metformin HCl"' showing total 5 results
Start Over Descriptor "Metformin HCl" Journal carbohydrate polymers
5 results on '"Metformin HCl"'

1. Trigonella foenum-graecum L. seed mucilage-gellan mucoadhesive beads for controlled release of metformin HCl.

Author

Nayak, Amit Kumar and Pal, Dilipkumar

Subjects
*FENUGREEK, *SEEDS, *MUCILAGE, *GELLAN gum, *ADHESIVES, *CONTROLLED release technology, *METFORMIN, *HYDROCHLORIC acid
Abstract

Highlights: [•] Ionotropically-gelled mucoadhesive beads of metformin HCl was developed. [•] These beads were made of fenugreek seed mucilage-gellan gum polymer-blend. [•] The in vitro drug release was prolonged over 10h and showed zero-order kinetics. [•] Optimized beads exhibited pH-dependent swelling and good bioadhesion. [•] These beads proved prolonged and significant hypoglycemic effect in diabetic rats. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Tamarind seed polysaccharide–gellan mucoadhesive beads for controlled release of metformin HCl.

Author

Nayak, Amit Kumar, Pal, Dilipkumar, and Santra, Kousik

Subjects
*LEGUMIN, *SEEDS, *POLYSACCHARIDES, *GELLAN gum, *METFORMIN, *CONTROLLED release drugs
Abstract

Highlights: [•] Ionically-gelled mucoadhesive beads of metformin HCl was developed and optimized. [•] These beads were made of tamarind seed polysaccharide–gellan gum polymer-blend. [•] The in vitro drug release showed zero-order with super case-II transport mechanism. [•] Optimized beads exhibited good mucoadhesivity with the biological mucous membrane. [•] These beads proved prolonged and significant hypoglycemic effect in diabetic rats. [ABSTRACT FROM AUTHOR]

Published
2014
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3. Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl.

Author

Nayak, Amit Kumar, Pal, Dilipkumar, and Santra, Kousik

Subjects
*CALCIUM compounds, *SEEDS, *POLYSACCHARIDES, *ADHESIVES, *METFORMIN, *HYDROCHLORIC acid, *POLYMER blends, *DRUG delivery systems
Abstract

Highlights: [•] Novel mucoadhesive beads of metformin HCl was developed and optimized. [•] Low methoxy (LM) pectin-tamarind seed polysaccharide polymer-blend was used. [•] The in vitro drug release followed zero-order with super case-II transport mechanism. [•] The optimized beads showed pH-sensitive swelling and good mucoadhesive property. [•] These beads proved prolonged and significant hypoglycemic effect in diabetic rats. [ABSTRACT FROM AUTHOR]

Published
2014
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4. Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl.

Author

Nayak, Amit Kumar, Pal, Dilipkumar, and Das, Sabinesh

Subjects
*METFORMIN, *HYDROCHLORIC acid, *PECTIC enzymes, *CALCIUM, *FENUGREEK, *MUCILAGE, *PROCESS optimization, *LABORATORY rats
Abstract

Highlights: [•] New ionically gelled mucoadhesive beads of metformin HCl was developed and optimized. [•] Pectin and fenugreek seed mucilage were used as polymer-blends. [•] These beads showed pH-sensitive swelling and good mucoadhesive property. [•] The in vitro drug release followed zero order with super case-II transport mechanism. [•] The optimized mucoadhesive beads proved prolonged hypoglycemic effect in diabetic rats. [ABSTRACT FROM AUTHOR]

Published
2013
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5. Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl

Author

Sabinesh Das, Dilipkumar Pal, and Amit Kumar Nayak

Subjects
Blood Glucose, Male, food.ingredient, Polymers and Plastics, Pectin, Metformin hcl, chemistry.chemical_element, Calcium, Diabetes Mellitus, Experimental, Plant Mucilage, food, Drug Delivery Systems, Oral administration, Adhesives, Materials Chemistry, Mucoadhesion, medicine, Animals, Hypoglycemic Agents, Intestinal Mucosa, Chromatography, Chemistry, Goats, Organic Chemistry, Factorial experiment, Metformin, Rats, Trigonella, Mucilage, Biochemistry, Seeds, Pectins, Female, Swelling, medicine.symptom
Abstract

Calcium pectinate-fenugreek seed mucilage (FSM) mucoadhesive beads containing metformin HCl was developed through ionic-gelation. Effects of pectin and FSM amounts on drug encapsulation efficiency (DEE) and cumulative drug release at 10 h (R10 h) were optimized using 32 factorial design. The DEE (%) was within the range of 63.16 ± 2.88 to 96.03 ± 4.67% (w/w). The in vitro drug release from these beads (56.64 ± 1.47 to 93.63 ± 4.52% over 10 h) was followed controlled-release (zero-order) pattern (R2 = 0.993 to 0.997) with super case-II transport mechanism. The average size of beads was within 1.47 ± 0.14 to 2.08 ± 0.18 mm. The beads were also characterized by SEM and FTIR. The swelling and mucoadhesivity of these beads were influenced by pH of the medium. The optimized beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.

Published
2013

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