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2. Surface-modified polylactic acid nanospheres with chitosan for antibacterial activity of 1, 2-benzisothiazolin-3-one

Author

Jingxia Liu, Hong-bing Tao, Heng Zhi, Xiaobao Xie, Junwei Yao, and Qingshan Shi

Subjects
Staphylococcus aureus, Polymers and Plastics, Polyesters, macromolecular substances, 1 2 benzisothiazolin 3 one, Chitosan, chemistry.chemical_compound, stomatognathic system, Polylactic acid, Materials Chemistry, Escherichia coli, Humans, Lactic Acid, Particle Size, EC50, chemistry.chemical_classification, Reactive oxygen species, Organic Chemistry, Surface modified, respiratory system, equipment and supplies, Bioavailability, Anti-Bacterial Agents, Oxidative Stress, Thiazoles, chemistry, Microscopy, Electron, Scanning, lipids (amino acids, peptides, and proteins), Antibacterial activity, Reactive Oxygen Species, Nanospheres, Nuclear chemistry
Abstract

The primary purpose of this study was to develop an innovative chitosan (CS) modified polylactic acid (PLA) nanospheres for enhancing the bioavailability of 1, 2-benzisothiazolin-3-one (BIT). The cellular uptake efficiency was corresponded positively to the quantity of CS coated on BIT-PLA nanospheres against E. coli and S. aureus. The membrane potentials of E.coli and S. aureus treated with BIT-PLA, BIT-PLA-0.1%CS and BIT-PLA-0.5%CS were reduced with the extension of incubation time and the ratio of coated CS. The enhancement of CS modified on BIT-PLA nanospheres was reduced antioxidase activities and generated excessive reactive oxygen species. The lowest EC50 value of the modified BIT-PLA-0.5%CS suggested that its toxicity index was around 2.95-fold and 2.11-fold that of non-modified BIT-PLA against E. coli and S. aureus, respectively. These results revealed that the CS modified BIT-PLA nanospheres had a bright prospect in antibacterial formulation delivery system and improving the bioavailability.

Published
2021

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