1. Effects of Captopril on the Physical Work Capacity of Normotensive Patients with Stable-Effort Angina pectoris
- Author
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Urso L, C. Strozzi, Francesco Portaluppi, Rizzo A, Loris Montanari, K. Al Yassini, Alfiero R, Tasini Mt, and Cocco G
- Subjects
Male ,medicine.medical_specialty ,Captopril ,Physical Exertion ,Physical exercise ,Placebo ,Angina Pectoris ,Coronary artery disease ,Angina ,Physical work capacity ,Internal medicine ,Heart rate ,Humans ,Medicine ,Pharmacology (medical) ,cardiovascular diseases ,biology ,business.industry ,Hemodynamics ,Angiotensin-converting enzyme ,Middle Aged ,Angiotensin inhibitor ,medicine.disease ,Angina pectoris ,Blood pressure ,Exercise Test ,biology.protein ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Twelve normotensive patients with coronary artery disease and stable effort-induced angina pectoris were selected: the antiischemic effect of captopril was studied. A maximal cycloergometer effort test was obtained before (base) and after administration of placebo or captopril (50 mg p.o.). The following parameters were measured: heart rate (HR), blood pressure (BP), maximal rate/pressure product (MRPP), maximal workload sustained, (MWS), maximal working time (MWT), and S-T depression at MRPP. The base and placebo were similar. Compared to them captopril augmented the MWT, increased the MWS, reduced S-T depression at MRPP, and decreased the number of patients with effort-induced angina pectoris. The antiischemic effect of captopril seems related both to its effect on HR and BP, and to a local enhancement of coronary blood flow.
- Published
- 1987
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