1. Treatment of advanced heart failure in adults with congenital heart disease: a narrative review and clinical cases
- Author
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Christoph Sinning, Michael Huntgeburth, Norihide Fukushima, Rose Tompkins, June Huh, Shigeru Tataneo, Gerhard-Paul Diller, Yih-Sharng Chen, Elvin Zengin, Christina Magnussen, Ann-Sophie Kaemmerer, Yang Hyun Cho, Stefan Blankenberg, Carsten Rickers, Frank Harig, Michael Weyand, Michael Hübler, Yskert von Kodolitsch, Öztekin Oto, Andreas Zuckermann, Paulus Kirchhof, Helmut Baumgartner, Hermann Reichenspurner, Jon Kobashigawa, Harald Kaemmerer, and Koichiro Niwa
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
Background and Objective: The number of adults with congenital heart disease (ACHD) is increasing worldwide. Almost all congenital cardiac lesions can be successfully treated due to the progress in neonatal surgery and pediatric cardiology with a high likelihood of surviving until adulthood. However, ACHD frequently develop sequelae related to the initial cardiac anomaly. Heart failure (HF) is one of the most common complications associated with a high morbidity and mortality.Methods: The authors did search the PubMed database regarding relevant content covering publications up to March 2022. Relevant manuscripts were classified according to the impact factor of the journal, being a guideline manuscript, a position paper by a society or a comprehensive review of the current literature. Key content and findings: Optimal HF treatment remains an unmet need in ACHD. In particular, advanced HF therapy with cardiac resynchronization therapy, ventricular assist devices or organ transplantation is still very different and more specific in ACHD compared to non-ACHD. This review aims to compile international views and evidence from the literatures on the treatment of advanced HF in ACHD. Current challenges, but also the success of different treatment strategies in ACHD are illustrated by clinical cases.Conclusions: The main finding of the review is that data is still scarce regarding ACHD with advanced HF and international efforts to collect data regarding these patients needed to improve the current standard of care.
- Published
- 2022