1. Paclitaxel-eluting balloon and everolimus-eluting stent for provisional stenting of coronary bifurcations: 12-month results of the multicenter BIOLUX-I study
- Author
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Randall Hendriks, Robert Whitbourn, Alan Whelan, Stephen G. Worthley, Matthew I. Worthley, Darren L. Walters, and Ian T Meredith
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Paclitaxel ,Bifurcation lesion ,medicine.medical_treatment ,Pilot Projects ,Coronary Artery Disease ,Coronary Angiography ,Prosthesis Design ,Balloon ,Coronary Restenosis ,Coronary artery disease ,Percutaneous Coronary Intervention ,Coated Materials, Biocompatible ,Restenosis ,Intravascular ultrasound ,medicine ,Humans ,Everolimus ,Prospective Studies ,Drug-eluting balloon ,Ultrasonography, Interventional ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Provisional stenting ,Australia ,Stent ,Percutaneous coronary intervention ,Cardiovascular Agents ,Drug-Eluting Stents ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Treatment Outcome ,Cardiovascular agent ,Feasibility Studies ,Female ,Radiology ,Drug-coated balloon ,business ,Cardiology and Cardiovascular Medicine ,Vascular Access Devices ,medicine.drug - Abstract
Background Several studies investigated the combination of bare metal stents in the main branch and drug-eluting balloons in the side branch in bifurcation lesions, but data on the combination of drug-eluting stents and drug-eluting balloons are scarce. We aim to assess the feasibility of provisional stenting with an everolimus-eluting stent in the main branch and a paclitaxel-eluting balloon in the side branch. Methods In this prospective, multi-center study conducted in 5 Australian sites, 35 patients with bifurcation lesions were enrolled. Angiographic and intravascular ultrasound assessments were conducted at 9 months; clinical follow-up was conducted until 12 months. Results The primary endpoint, late lumen loss in the side branch measured by quantitative coronary angiography, was 0.10 ± 0.43 mm. No binary restenosis was observed. One patient died; 3 myocardial infarctions (one suspected and two in non-target vessels) and one target lesion revascularization occurred. No probable or definite stent thrombosis was observed. Conclusion The combination of an everolimus-eluting stent in the main branch and a paclitaxel-eluting balloon in the side branch appears to be a safe, effective and novel treatment option for bifurcation lesions.
- Published
- 2015
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