1. Association of high level of hs-CRP with in-stent restenosis: A case-control study.
- Author
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Baktashian M, Saffar Soflaei S, Kosari N, Salehi M, Khosravi A, Ahmadinejad M, Moohebati M, Ebrahimi M, Rahmani F, Khameneh-Bagheri R, Ahmadi M, Sadabadi F, Tayefi M, Bazhdanzadeh S, Ferns GA, Hashemi SM, Pasdar A, and Ghayour-Mobarhan M
- Subjects
- Aged, Biomarkers blood, Case-Control Studies, Coronary Artery Disease blood, Coronary Artery Disease diagnostic imaging, Coronary Restenosis blood, Coronary Restenosis diagnosis, Diabetes Mellitus, Female, Humans, Iran, Male, Middle Aged, Predictive Value of Tests, Prosthesis Design, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Up-Regulation, C-Reactive Protein analysis, Coronary Artery Disease therapy, Coronary Restenosis etiology, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention instrumentation, Stents
- Abstract
Background: In-stent restenosis (ISR) is one adverse outcome of coronary stent implantation. Although using drug-eluting stents has reduced the rate of ISR, it remains a major problem. Here, we have investigated the relationship between several patient characteristics including serum high sensitive C-reactive protein (hs-CRP) and ISR., Methods: This was a case-control study comprising 104 individuals with ISR and 202 patients without. Baseline characteristics were collected using a questionnaire. Fasting blood glucose (FBG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and serum high sensitivity C-reactive protein (hs-CRP) were measured using commercial kits on an auto-analyzer. Data were analyzed using SPSS software and a p value ≤ 0.05 was considered significant., Results: Diabetes mellitus (p < 0.001), stent type (p = 0.005), serum hs-CRP (p = 0.006), FBG (p = 0.038) and serum TG (p = 0.039) were significantly associated with ISR. The association between hs-CRP and ISR remained significant after adjustment for stent type and DM. For patients with a serum hs-CRP <2.64 mg/dL, ISR was only associated with diabetes mellitus (p = 0.016); while for individuals with a serum hs-CRP ≥2.64 mg/dL, ISR was also associated with the presence of diabetes mellitus, serum triglycerides and stent type., Conclusion: Higher levels of serum hs-CRP were significantly associated with the occurrence of ISR., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2019
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