1. Left ventricular markers of global dyssynchrony predict limited exercise capacity in heart failure, but not in patients with preserved ejection fraction
- Author
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Bajraktari Gani, Batalli Arlind, Poniku Afrim, Ahmeti Artan, Olloni Rozafa, Hyseni Violeta, Vela Zana, Morina Besim, Tafarshiku Rina, Vela Driton, Rashiti Premtim, Haliti Edmond, and Henein Michael Y
- Subjects
Six-minute walk test ,Doppler echocardiography ,LV function and dyssynchrony ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background The aim of this study was to prospectively examine echocardiographic parameters that correlate and predict functional capacity assessed by 6 min walk test (6-MWT) in patients with heart failure (HF), irrespective of ejection fraction (EF). Methods In 147 HF patients (mean age 61 ± 11 years, 50.3% male), a 6-MWT and an echo-Doppler study were performed in the same day. Global LV dyssynchrony was indirectly assessed by total isovolumic time - t-IVT [in s/min; calculated as: 60 – (total ejection time + total filling time)], and Tei index (t-IVT/ejection time). Patients were divided into two groups based on the 6-MWT distance (Group I: ≤300 m and Group II: >300 m), and also in two groups according to EF (Group A: LVEF ≥ 45% and Group B: LVEF Results In the cohort of patients as a whole, the 6-MWT correlated with t-IVT (r = −0.49, p Conclusion In patients with HF, the limited exercise capacity, assessed by 6-MWT, is related mostly to severity of global LV dyssynchrony, more than EF or raised filling pressures. The lack of exercise predictors in HFpEF reflects its multifactorial pathophysiology.
- Published
- 2012
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