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Start Over Author "Alex Mira" Journal caries research
3 results on '"Alex Mira"'

1. Contents Vol. 47, 2013

Author

Nadine Schlueter, Y.-P. Zhang, Satz Mengensatzproduktion, Jan L Ruben, Heejin Kim, RP Shellis, William DeVizio, A. Jesani, Marie-Charlotte D.N.J.M. Huysmans, Elmar Hellwig, Roger Ellwood, Druck Reinhardt Druck Basel, Pamela Hasslöf, Michele E Barbour, K.-Y. Song, Sebastian Paris, Majid Akbari, Carolina Ganss, Joachim Klimek, Christina Stecksén-Blicks, Petcharat Kraivaphan, H.H. Zarch, F. Karlsson Videhult, Aurea Simon-Soro, H. Meyer-Lueckel, Christof E. Dörfer, N. Zwier, Falko Goetz, Raúl Cabrera-Rubio, Pedro Belda-Ferre, Triratana T, G.J. Truin, Ewald M. Bronkhorst, J.-G. Jeon, F. Movagharipour, S. Pandit, Alex Mira, Falk Schwendicke, D. H. J. Jager, Cholticha Amornchat, Luis David Alcaraz, C. Brandelius, Farzaneh Ahrari, D. Cummins, Luis R Mateo, Christina E. West, and Adrian Lussi

Subjects
General Dentistry
Published
2013

2. Dental Caries from a Molecular Microbiological Perspective

Author

Alex Mira, Nobuhiro Takahashi, David Beighton, Wim Crielaard, Bente Nyvad, Preventive Dentistry, and Preventieve tandheelkunde (OII, ACTA)

Subjects
business.industry, Biofilm, Microbial composition, Dental Caries, biochemical phenomena, metabolism, and nutrition, Integrated approach, Biology, Biotechnology, RNA, Bacterial, Genetic Techniques, Metagenomics, Biofilms, RNA, Ribosomal, 16S, Metabolome, Humans, Metagenome, Transcriptome, Metabolic activity, business, General Dentistry
Abstract

Dental caries results from an imbalance of the metabolic activity in the dental biofilm. The microbial communities of teeth have traditionally been studied by standard cultural approaches. More recently, cloning and sequencing of the 16S rRNA gene have been used to characterize the microbial composition of the oral biofilm, but the methodological limitations of this approach have now been recognized. Next-generation high-throughput sequencing methods have the potential to reveal the composition and functioning of the biofilm by means of metagenomic and metatranscriptomic analyses. Currently available high-throughput sequencing approaches are reviewed and discussed in relation to studying the biofilm associated with dental caries. Important in understanding the dynamic processes in caries is the metabolic activity of the biofilm; metabolome analysis is a new tool that might enable us to assess such activity. As caries is a localized disease, it is essential that biofilm samples are taken from precisely determined tooth sites; pooling samples is not appropriate. This paper presents the case that culture-based studies are important, but that the fullest understanding of the role of the biofilm in the caries process will only come from an integrated approach determining biological function and metabolic output.

Published
2012

3. 61st Annual ORCA Congress 2014

Author

Ewald M. Bronkhorst, S. Pandit, Petcharat Kraivaphan, Joachim Klimek, Falko Goetz, Raúl Cabrera-Rubio, Farzaneh Ahrari, Jan L Ruben, Nadine Schlueter, Michele E Barbour, F. Movagharipour, Majid Akbari, H.H. Zarch, Carolina Ganss, A. Jesani, D. Cummins, Aurea Simon-Soro, Satz Mengensatzproduktion, Sebastian Paris, Pamela Hasslöf, Luis R Mateo, Heejin Kim, Pedro Belda-Ferre, RP Shellis, D. H. J. Jager, William DeVizio, J.-G. Jeon, Roger Ellwood, Druck Reinhardt Druck Basel, G.J. Truin, F. Karlsson Videhult, K.-Y. Song, Triratana T, Falk Schwendicke, Cholticha Amornchat, Luis David Alcaraz, Christina E. West, C. Brandelius, N. Zwier, Adrian Lussi, H. Meyer-Lueckel, Y.-P. Zhang, Elmar Hellwig, Marie-Charlotte D.N.J.M. Huysmans, Christof E. Dörfer, Christina Stecksén-Blicks, and Alex Mira

Subjects
Pregnancy, business.industry, Immunology, medicine, Congenital cytomegalovirus infection, medicine.disease, business, General Dentistry
Published
2013

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