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Systemic lupus erythematosus (SLE) is a chronic inflammatory disorderwith unknown etiology which can involve various organs in the body. The most common symptoms of this disease are constitutional symptoms along with skin rashes, arthritis, nephrologic, and hematologic manifestations. Acute pancreatitis is an unusual presentation of SLE. Here, we report an interesting case SLE who suffered from fever, weakness, abdominal pain, and weight loss. Finally, lupuspancreatitis was diagnosed based on her symptoms, laboratory, and imaging findings.