1. Chronic Diarrhea Secondary to Newly Diagnosed VIPoma
- Author
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Justin R. Boike, Domenico A. Farina, and Katrina Krogh
- Subjects
Diarrhea ,medicine.medical_specialty ,Single Case ,Octreotide ,Stain ,Gastroenterology ,Malaise ,03 medical and health sciences ,0302 clinical medicine ,Pancreatic neuroendocrine tumor ,Internal medicine ,Medicine ,lcsh:RC799-869 ,VIPoma ,Osmole ,biology ,business.industry ,Chromogranin A ,medicine.disease ,Hypokalemia ,030220 oncology & carcinogenesis ,biology.protein ,030211 gastroenterology & hepatology ,lcsh:Diseases of the digestive system. Gastroenterology ,medicine.symptom ,business ,medicine.drug - Abstract
Vasoactive intestinal polypeptide-secreting tumors (VIPoma) are a rare pancreatic neuroendocrine tumor that can cause chronic diarrhea with 1 case per 10 million people per year. Diagnosis is made based on a combination of laboratory evaluation (serum VIP level), imaging findings (functional positron emission tomography-computed tomography [PET-CT]), and histological analysis (chromogranin A stain). We present a case of a male with 6 months of diarrhea and malaise who was found to have significant kidney injury and hypokalemia requiring admission to the medical intensive care unit. Subsequent laboratory evaluation while admitted eventually showed a low stool osmotic gap (–11 mOsm/kg) consistent with secretory diarrhea, in addition to significantly elevated VIP levels at 940 pg/mL (normal
- Published
- 2019