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1. Identification of intrinsic determinants of midbrain dopamine neurons

Author

Andersson, Elisabet, Tryggvason, Ulrika, Deng, Qiaolin, Frilling, Stina, Alekseenko, Zhanna, Robert, Benoit, Perlmann, Thomas, and Ericson, Johan

Subjects
Biological sciences
Abstract

The homeodomain proteins Lmx1a and Msx1 function as determinants of midbrain dopamine neurons, cells that degenerate in patients with Parkinson's disease, as Lmx1a is sufficient and required to trigger dopamine cell differentiation. Lmx1a and Msx1 are critical intrinsic dopamine-neuron determinants in vivo and suggest that they may be essential tools in cell replacement strategies in Parkinson's disease.

Published
2006

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