Search

Your search keyword '"L'Etoile, Noelle D."' showing total 2 results
Start Over Author "L'Etoile, Noelle D." Journal cell
2 results on '"L'Etoile, Noelle D."'

1. Sleep is required to consolidate odor memory and remodel olfactory synapses

Author

Chandra, Rashmi, Farah, Fatima, Muñoz-Lobato, Fernando, Bokka, Anirudh, Benedetti, Kelli L., Brueggemann, Chantal, Saifuddin, Mashel Fatema A., Miller, Julia M., Li, Joy, Chang, Eric, Varshney, Aruna, Jimenez, Vanessa, Baradwaj, Anjana, Nassif, Cibelle, Alladin, Sara, Andersen, Kristine, Garcia, Angel J., Bi, Veronica, Nordquist, Sarah K., Dunn, Raymond L., Garcia, Vanessa, Tokalenko, Kateryna, Soohoo, Emily, Briseno, Fabiola, Kaur, Sukhdeep, Harris, Malcolm, Guillen, Hazel, Byrd, Decklin, Fung, Brandon, Bykov, Andrew E., Odisho, Emma, Tsujimoto, Bryan, Tran, Alan, Duong, Alex, Daigle, Kevin C., Paisner, Rebekka, Zuazo, Carlos E., Lin, Christine, Asundi, Aarati, Churgin, Matthew A., Fang-Yen, Christopher, Bremer, Martina, Kato, Saul, VanHoven, Miri K., and L’Étoile, Noëlle D.

Published
2023
Full Text
View/download PDF

2. Endogenous Nuclear RNAi Mediates Behavioral Adaptation to Odor

Author

Juang, Bi-Tzen, Gu, Chen, Starnes, Linda, Palladino, Francesca, Goga, Andrei, Kennedy, Scott, and L’Etoile, Noelle D

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Neurosciences, Biotechnology, Genetics, Generic health relevance, Adaptation, Physiological, Animals, Butanones, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Chromosomal Proteins, Non-Histone, Cyclic GMP-Dependent Protein Kinases, Down-Regulation, Guanylate Cyclase, Odorants, Phosphorylation, RNA Interference, RNA, Helminth, RNA, Small Interfering, RNA-Binding Proteins, Sensory Receptor Cells, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Most eukaryotic cells express small regulatory RNAs. The purpose of one class, the somatic endogenous siRNAs (endo-siRNAs), remains unclear. Here, we show that the endo-siRNA pathway promotes odor adaptation in C. elegans AWC olfactory neurons. In adaptation, the nuclear Argonaute NRDE-3, which acts in AWC, is loaded with siRNAs targeting odr-1, a gene whose downregulation is required for adaptation. Concomitant with increased odr-1 siRNA in AWC, we observe increased binding of the HP1 homolog HPL-2 at the odr-1 locus in AWC and reduced odr-1 mRNA in adapted animals. Phosphorylation of HPL-2, an in vitro substrate of the EGL-4 kinase that promotes adaption, is necessary and sufficient for behavioral adaptation. Thus, environmental stimulation amplifies an endo-siRNA negative feedback loop to dynamically repress cognate gene expression and shape behavior. This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene expression and promote cellular memory formation. PAPERFLICK:

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results