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9 results on '"Lin, Charles Y."'

1. Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

Author

Bowling, Elizabeth A., primary, Wang, Jarey H., additional, Gong, Fade, additional, Wu, William, additional, Neill, Nicholas J., additional, Kim, Ik Sun, additional, Tyagi, Siddhartha, additional, Orellana, Mayra, additional, Kurley, Sarah J., additional, Dominguez-Vidaña, Rocio, additional, Chung, Hsiang-Ching, additional, Hsu, Tiffany Y.-T., additional, Dubrulle, Julien, additional, Saltzman, Alexander B., additional, Li, Heyuan, additional, Meena, Jitendra K., additional, Canlas, Gino M., additional, Chamakuri, Srinivas, additional, Singh, Swarnima, additional, Simon, Lukas M., additional, Olson, Calla M., additional, Dobrolecki, Lacey E., additional, Lewis, Michael T., additional, Zhang, Bing, additional, Golding, Ido, additional, Rosen, Jeffrey M., additional, Young, Damian W., additional, Malovannaya, Anna, additional, Stossi, Fabio, additional, Miles, George, additional, Ellis, Matthew J., additional, Yu, Lihua, additional, Buonamici, Silvia, additional, Lin, Charles Y., additional, Karlin, Kristen L., additional, Zhang, Xiang H.-F., additional, and Westbrook, Thomas F., additional

Published
2021
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2. BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

Author

Anand, Priti, primary, Brown, Jonathan D., additional, Lin, Charles Y., additional, Qi, Jun, additional, Zhang, Rongli, additional, Artero, Pedro Calderon, additional, Alaiti, M. Amer, additional, Bullard, Jace, additional, Alazem, Kareem, additional, Margulies, Kenneth B., additional, Cappola, Thomas P., additional, Lemieux, Madeleine, additional, Plutzky, Jorge, additional, Bradner, James E., additional, and Haldar, Saptarsi M., additional

Published
2013
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6. Revisiting Global Gene Expression Analysis

Author

Lovén, Jakob, primary, Orlando, David A., additional, Sigova, Alla A., additional, Lin, Charles Y., additional, Rahl, Peter B., additional, Burge, Christopher B., additional, Levens, David L., additional, Lee, Tong Ihn, additional, and Young, Richard A., additional

Published
2012
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8. c-Myc Regulates Transcriptional Pause Release

Author

Rahl, Peter B., primary, Lin, Charles Y., additional, Seila, Amy C., additional, Flynn, Ryan A., additional, McCuine, Scott, additional, Burge, Christopher B., additional, Sharp, Phillip A., additional, and Young, Richard A., additional

Published
2010
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9. c-Myc Regulates Transcriptional Pause Release

Author

Peter B. Rahl, Ryan A. Flynn, Christopher B. Burge, Phillip A. Sharp, Richard A. Young, Amy C. Seila, Charles Y. Lin, Scott McCuine, Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Burge, Christopher B., Lin, Charles Y., Seila, Amy C., Flynn, Ryan A., Sharp, Phillip A., and Young, Richard A.

Subjects
Chromatin Immunoprecipitation, Transcription, Genetic, RNA polymerase II, Enhancer RNAs, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Mice, 0302 clinical medicine, Animals, Humans, Promoter Regions, Genetic, RNA polymerase II holoenzyme, Embryonic Stem Cells, 030304 developmental biology, Cell Proliferation, Genetics, 0303 health sciences, biology, General transcription factor, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, DNA, STEMCELL, 3. Good health, 030220 oncology & carcinogenesis, biology.protein, RNA, Transcription factor II F, Transcription factor II E, RNA Polymerase II, Transcription factor II D, Transcriptional Elongation Factors, Transcription factor II B, Octamer Transcription Factor-3, Transcription Factors
Abstract

Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized as a key regulatory step in gene expression. We report here that promoter-proximal pausing is a general feature of transcription by Pol II in mammalian cells and thus an additional step where regulation of gene expression occurs. This suggests that some transcription factors recruit the transcription apparatus to promoters, whereas others effect promoter-proximal pause release. Indeed, we find that the transcription factor c-Myc, a key regulator of cellular proliferation, plays a major role in Pol II pause release rather than Pol II recruitment at its target genes. We discuss the implications of these results for the role of c-Myc amplification in human cancer., National Institutes of Health (U.S.) (Grant number RO1-HG002668), National Institutes of Health (U.S.) (Grant number RO1-GM34277), National Institutes of Health (U.S.) (Grant number RO1-CA133404), National Cancer Institute (U.S.) (Grant Number PO1- CA42063), National Cancer Institute (U.S.) Cancer Center Support Grant (Grant Number P30-CA14051), National Institutes of Health (U.S.) Postdoctoral Fellowship (5-F32-HD051190)

Published
2010
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