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11 results on '"Moffat, Jason"'

2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

Author

Gupta, Gagan D., Coyaud, Étienne, Gonçalves, João, Mojarad, Bahareh A., Liu, Yi, Wu, Qianzhu, Gheiratmand, Ladan, Comartin, David, Tkach, Johnny M., Cheung, Sally W.T., Bashkurov, Mikhail, Hasegan, Monica, Knight, James D., Lin, Zhen-Yuan, Schueler, Markus, Hildebrandt, Friedhelm, Moffat, Jason, Gingras, Anne-Claude, Raught, Brian, and Pelletier, Laurence

Published
2015
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3. Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Author

Rehman, Sumaiyah K., primary, Haynes, Jennifer, additional, Collignon, Evelyne, additional, Brown, Kevin R., additional, Wang, Yadong, additional, Nixon, Allison M.L., additional, Bruce, Jeffrey P., additional, Wintersinger, Jeffrey A., additional, Singh Mer, Arvind, additional, Lo, Edwyn B.L., additional, Leung, Cherry, additional, Lima-Fernandes, Evelyne, additional, Pedley, Nicholas M., additional, Soares, Fraser, additional, McGibbon, Sophie, additional, He, Housheng Hansen, additional, Pollet, Aaron, additional, Pugh, Trevor J., additional, Haibe-Kains, Benjamin, additional, Morris, Quaid, additional, Ramalho-Santos, Miguel, additional, Goyal, Sidhartha, additional, Moffat, Jason, additional, and O’Brien, Catherine A., additional

Published
2021
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5. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

Author

Moffat, Jason, Grueneberg, Dorre A., Xiaoping Yang, So Young Kim, Kloepfer, Angela M., Hinkle, Gregory, Piqani, Bruno, Eisenhaure, Thomas M., Luo, Blao, Grenler, Jennifer K., Carpenter, Anne E., Shi Yin Foo, Stewart, Sheila A., Stockwell, Brent R., Hacohen, Nir, Hahn, William C., Lander, Eric S., Sabatini, David M., and Root, David E.

Subjects
Cell cycle -- Research, RNA -- Research, Cell proliferation -- Research, Nucleotide sequencing -- Research, Biological sciences
Abstract

A screen based on high-content imaging is developed to test the utility of the library for arrayed screens in order to identify genes required for mitotic progression in human cancer cells and applied to an arrayed set of 5,000 unique short hairpin RNA (shRNA)-expressing lentiviruses that target 1,028 human genes. The screen identified several known and ~100 candidate regulators of mitotic progression and proliferation.

Published
2006

6. Exploration of essential gene functions via titratable promoter alleles

Author

Mnaimneh, Sanie, Davierwala, Armaity P., Haynes, Jennifer, Moffat, Jason, Peng, Wen-Tao, Zhang, Wen, Yang, Xueqi, Pootoolal, Jeff, Chua, Gordon, Lopez, Andres, Trochesset, Miles, Morse, Darcy, Krogan, Nevan J., Morris, Quaid, Li, Zhijian, Hiley, Shawna L., Grigull, Jorg, Mitsakakis, Nicholas; Roberts, Christopher J.; Greenblatt, Jack F., and Boone, Charles; Kaiser, Chris A.; Andrews, Brenda J.; Hughes, Timothy R.

Subjects
DNA microarrays -- Research, Yeast fungi -- Genetic aspects, Yeast fungi -- Research, Genetic research, Biological sciences
Abstract

Essential yeast genes were subjected to morphological analysis, size profiling, drug sensitivity screening and microarray expression profiling for determining the essential gene functions. The study provides a resource to complement the yeast knockout collection and the automated genetic analysis confirms the compatibility of the yeast strains.

Published
2004

7. Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

Author

Marcotte, Richard, primary, Sayad, Azin, additional, Brown, Kevin R., additional, Sanchez-Garcia, Felix, additional, Reimand, Jüri, additional, Haider, Maliha, additional, Virtanen, Carl, additional, Bradner, James E., additional, Bader, Gary D., additional, Mills, Gordon B., additional, Pe’er, Dana, additional, Moffat, Jason, additional, and Neel, Benjamin G., additional

Published
2016
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10. Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate

Author

Findlay, Greg M., primary, Smith, Matthew J., additional, Lanner, Fredrik, additional, Hsiung, Marilyn S., additional, Gish, Gerald D., additional, Petsalaki, Evangelia, additional, Cockburn, Katie, additional, Kaneko, Tomonori, additional, Huang, Haiming, additional, Bagshaw, Richard D., additional, Ketela, Troy, additional, Tucholska, Monika, additional, Taylor, Lorne, additional, Bowtell, David D., additional, Moffat, Jason, additional, Ikura, Mitsuhiko, additional, Li, Shawn S.C., additional, Sidhu, Sachdev S., additional, Rossant, Janet, additional, and Pawson, Tony, additional

Published
2013
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