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1. Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

Author

Roux, Isabelle, Safieddine, Saaid, Nouvian, Regis, Grati, M'hamed, Simmler, Marie-Christine, Bahloul, Amel, Perfettini, Isabelle, Le Gall, Morgane, Rostaing, Philippe, Hamard, Ghislaine, Triller, Antoine, Avan, Paul, Moser, Tobias, and Petit, Christine

Subjects
Membrane proteins -- Research, Exocytosis -- Research, Synaptic vesicles -- Research, Biological sciences
Abstract

Otoferlin, a predicted C2-domain transmembrane protein, which is defective in a recessive form of human deafness, is studied. It shows that otoferlin expression in the hair cells correlates with afferent synaptogenesis and otoferlin localizes to ribbon-associated synaptic vesicles.

Published
2006

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