1. Toward a Common Coordinate Framework for the Human Body
- Author
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John C. Marioni, Tim Stuart, Shila Ghazanfar, Rahul Satija, Eyal Fisher, Gökcen Eraslan, Tommaso Biancalani, Leslie Gaffney, Anna Hupalowska, Andrew Butler, William M. Mauck, Jennifer Rood, Aviv Regev, and Massachusetts Institute of Technology. Department of Biology
- Subjects
Diagnostic Imaging ,0303 health sciences ,Genetic heterogeneity ,Emerging technologies ,Spatially resolved ,Anatomic Variation ,Human body ,Biology ,Reference Standards ,Data science ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Profiling (information science) ,Humans ,Cellular organization ,Reference standards ,Physical Examination ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
Understanding the genetic and molecular drivers of phenotypic heterogeneity across individuals is central to biology. As new technologies enable fine-grained and spatially resolved molecular profiling, we need new computational approaches to integrate data from the same organ across different individuals into a consistent reference and to construct maps of molecular and cellular organization at histological and anatomical scales. Here, we review previous efforts and discuss challenges involved in establishing such a common coordinate framework, the underlying map of tissues and organs. We focus on strategies to handle anatomical variation across individuals and highlight the need for new technologies and analytical methods spanning multiple hierarchical scales of spatial resolution., National Institutes of Health (U.S.). The Human BioMolecular Atlas Program (Grant NIH 1OT2OD026673- 01), National Institutes of Health (U.S.). New Innovator Award (1DP2HG009623- 01), Chan Zuckerberg Initiative (Grant HCA2-A-1708-02755)
- Published
- 2019