1. Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.
- Author
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Aid M, Abbink P, Larocca RA, Boyd M, Nityanandam R, Nanayakkara O, Martinot AJ, Moseley ET, Blass E, Borducchi EN, Chandrashekar A, Brinkman AL, Molloy K, Jetton D, Tartaglia LJ, Liu J, Best K, Perelson AS, De La Barrera RA, Lewis MG, and Barouch DH
- Subjects
- Animals, Cerebrospinal Fluid virology, Inflammation immunology, Lower Gastrointestinal Tract virology, Lymph Nodes virology, Macaca mulatta, Signal Transduction, TOR Serine-Threonine Kinases metabolism, Zika Virus Infection immunology, Zika Virus Infection virology
- Abstract
Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies correlated with rapid clearance of virus in peripheral blood but remained undetectable in CSF for the duration of the study. Viral persistence in both CSF and LN correlated with upregulation of mechanistic target of rapamycin (mTOR), proinflammatory, and anti-apoptotic signaling pathways, as well as downregulation of extracellular matrix signaling pathways. These data raise the possibility that persistent or occult neurologic and lymphoid disease may occur following clearance of peripheral virus in ZIKV-infected individuals., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2017
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