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4 results on '"Wulf, Gerburg"'

1. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

Author

Koikawa, Kazuhiro, Kibe, Shin, Suizu, Futoshi, Sekino, Nobufumi, Kim, Nami, Manz, Theresa D., Pinch, Benika J., Akshinthala, Dipikaa, Verma, Ana, Gaglia, Giorgio, Nezu, Yutaka, Ke, Shizhong, Qiu, Chenxi, Ohuchida, Kenoki, Oda, Yoshinao, Lee, Tae Ho, Wegiel, Babara, Clohessy, John G., London, Nir, Santagata, Sandro, Wulf, Gerburg M., Hidalgo, Manuel, Muthuswamy, Senthil K., Nakamura, Masafumi, Gray, Nathanael S., Zhou, Xiao Zhen, and Lu, Kun Ping

Published
2021
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2. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

Author

Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A, Lien, Evan C, Albeck, John G, Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R, Tolan, Dean R, Grant, Aaron K, Needleman, Daniel J, Asara, John M, Cantley, Lewis C, and Wulf, Gerburg M

Subjects
Underpinning research, 1.1 Normal biological development and functioning, Animals, Breast Neoplasms, Cell Line, Tumor, Cytoskeleton, Cytosol, Disease Models, Animal, Epithelial Cells, Fructose-Bisphosphate Aldolase, Glycolysis, Humans, Insulin, Mice, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose metabolism and also cytoskeletal functions, such as cell movement and attachment. Here, we show that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin stimulate the PI3K-dependent activation of Rac, leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase A, and an increase in aldolase activity. Consistently, PI3K inhibitors, but not AKT, SGK, or mTOR inhibitors, cause a significant decrease in glycolysis at the step catalyzed by aldolase, while activating PIK3CA mutations have the opposite effect. These results point toward a master regulatory function of PI3K that integrates an epithelial cell's metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive dynamics of actin remodeling.

Published
2016

3. Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors

Author

Emerling, Brooke M., Hurov, Jonathan B., Poulogiannis, George, Tsukazawa, Kazumi S., Choo-Wing, Rayman, Wulf, Gerburg M., Bell, Eric L., Shim, Hye-Seok, Lamia, Katja A., Rameh, Lucia E., Bellinger, Gary, Sasaki, Atsuo T., Asara, John M., Yuan, Xin, Bullock, Andrea, DeNicola, Gina M., Song, Jiaxi, Brown, Victoria, Signoretti, Sabina, and Cantley, Lewis C.

Published
2013
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4. PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

Author

Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., and Vander Heiden, Matthew G.

Published
2013
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