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Start Over Author "Minggang Peng" Journal cell adhesion & migration
2 results on '"Minggang Peng"'

1. Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

Author

Honglei Jin, Lei Xue, Lan Mo, Dongyun Zhang, Xirui Guo, Jiheng Xu, Jingxia Li, Minggang Peng, Xuewei Zhao, Minghao Zhong, Dazhong Xu, Xue-Ru Wu, Haishan Huang, and Chuanshu Huang

Subjects
xiap, mir-200c, bladder cancer, invasion/metastasis, creb inactivation, Cytology, QH573-671
Abstract

Our previous studies have demonstrated that XIAP promotes bladder cancer metastasis through upregulating RhoGDIβ/MMP-2 pathway. However, the molecular mechanisms leading to the XIAP upregulation was unclear. In current studies, we found that XIAP was overexpressed in human high grade BCs, high metastatic human BCs, and in mouse invasive BCs. Mechanistic studies indicated that XIAP overexpression in the highly metastatic T24T cells was due to increased mRNA stability of XIAP that was mediated by downregulated miR-200c. Moreover, the downregulated miR-200c was due to CREB inactivation, while miR-200c downregulation reduced its binding to the 3’-UTR region of XIAP mRNA. Collectively, our results demonstrate the molecular basis leading to XIAP overexpression and its crucial role in BC invasion.

Published
2019
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2. Downregulation of miR-200c stabilizes XIAP mRNA and contributes to invasion and lung metastasis of bladder cancer

Author

Jiheng Xu, Lan Mo, Da-Zhong Xu, Minghao Zhong, Lei Xue, Xirui Guo, Minggang Peng, Xue-Ru Wu, Xuewei Zhao, Chuanshu Huang, Honglei Jin, Haishan Huang, Jingxia Li, and Dongyun Zhang

Subjects
0301 basic medicine, Untranslated region, Lung Neoplasms, Down-Regulation, mir-200c, X-Linked Inhibitor of Apoptosis Protein, CREB, Metastasis, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Downregulation and upregulation, Cell Movement, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, RNA, Messenger, lcsh:QH573-671, Cyclic AMP Response Element-Binding Protein, creb inactivation, Cell Proliferation, Messenger RNA, Bladder cancer, xiap, biology, lcsh:Cytology, Chemistry, invasion/metastasis, Cell Biology, medicine.disease, 3. Good health, XIAP, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, MicroRNAs, 030104 developmental biology, Urinary Bladder Neoplasms, 030220 oncology & carcinogenesis, biology.protein, Cancer research, bladder cancer, Mir 200c, Research Paper
Abstract

Our previous studies have demonstrated that XIAP promotes bladder cancer metastasis through upregulating RhoGDIβ/MMP-2 pathway. However, the molecular mechanisms leading to the XIAP upregulation was unclear. In current studies, we found that XIAP was overexpressed in human high grade BCs, high metastatic human BCs, and in mouse invasive BCs. Mechanistic studies indicated that XIAP overexpression in the highly metastatic T24T cells was due to increased mRNA stability of XIAP that was mediated by downregulated miR-200c. Moreover, the downregulated miR-200c was due to CREB inactivation, while miR-200c downregulation reduced its binding to the 3’-UTR region of XIAP mRNA. Collectively, our results demonstrate the molecular basis leading to XIAP overexpression and its crucial role in BC invasion.

Published
2019

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